FAMILIAL IGA NEPHROPATHY: GENETIC AND FAMILIAL STUDIES

家族性 IGA 肾病：遗传和家族研究

• 批准号: 7380415
• 负责人: BRUCE A JULIAN
• 金额: $ 1.57万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7380415
• 关键词: FAMILIAL; IGA; NEPHROPATHY; GENETIC; STUDIES

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will provide clinical resources for the Clinical and Biostatistics Core of a multicenter Program Project that is comprised of three projects investigating the genetic and biochemical aspects of IgA nephropathy. The Specific Aims of this study are: 1. Measure blood pressure, height, and weight for participants seen in the UAB GCRC. 2. Collect venous blood and urine samples during the one outpatient visit for the participants seen at UAB GCRC. 3. Perform urinalysis, serum creatinine concentration, and urinary protein and creatinine concentrations for all 1515 participants using blood and urine samples either collected in the UAB GCRC or by UAB investigators during field trips, or sent from participating outside centers. 4. Establish EBV-transofrmed cell lines for some participants, to be selected by the investigators based upon their potential to contribute to the genetic studies of familial IgA nephropathy. The findings from this Program Project will substantially increase the understanding of the pathogenesis of a common renal disease and may be the foundation for future development of a disease-specific therapy.

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。这项研究将为临床和生物统计学核心的一个多中心项目提供临床资源，该项目由三个研究IgA肾病遗传和生化方面的项目组成。本研究的具体目的是：1。测量UAB GCRC中参与者的血压、身高和体重。2. 在UAB GCRC的一次门诊期间，收集参与者的静脉血和尿液样本。3. 对所有1515名参与者进行尿液分析，血清肌酐浓度，尿蛋白和肌酐浓度，使用UAB GCRC收集的血液和尿液样本，或由UAB调查员在实地考察期间收集的样本，或从参与的外部中心发送的样本。4. 为一些参与者建立ebv转化细胞系，由研究人员根据其对家族性IgA肾病的遗传研究的潜力进行选择。本项目的研究结果将大大增加对常见肾脏疾病发病机制的了解，并可能为未来疾病特异性治疗的发展奠定基础。