Molecular Determinants of Oral Cancer Detection

口腔癌检测的分子决定因素

• 批准号: 7303760
• 负责人: XIAOFENG ZHOU
• 金额: $ 7.57万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7303760
• 关键词: bioinformatics; biotechnology; clinical research; early diagnosis; gene expression; gene expression profiling; gene mutation; genetic mapping; genetic markers; genetic transcription; head /neck neoplasm; human tissue; laser capture microdissection; loss of heterozygosity; microarray technology; molecular oncology; mouth neoplasms; neoplasm /cancer diagnosis; neoplasm /cancer genetics; polymerase chain reaction; single nucleotide polymorphism; squamous cell carcinoma

DESCRIPTION (provided by applicant): Oral squamous cell carcinoma (SCC) is the sixth most common cancer worldwide accounting for 4% of cancers in men and 2% of cancers in women. In the United States there are over 38,000 new cases of oral cancer each year. The overall 5-year survival rates for oral cancer have remained low at approximately 30-40% for the past decades and has remain among the worst of all cancer death rates. This is dispointing and points to the needs for new strategy for prevention, diagnosis and treatment of this disease. This proposal aims to harness the molecular determinants of oral SCC using genomic and expressional approaches on patient population that will permit the maximal utility of emerging technologies to identify concordant genomic and transcriptional determinants in oral cancer. The combined power of SNP array-based loss of heterozygosity (LOH) and copy number abnormalities (CNA) profiling (Aim 1) and the comprehensive differential expression profiling (Aim 2) will be utilized. The advantages of this type of synergistic approach are significant. For example, if the same gene shows DNA copy number abnormalities and altered expression, not only do we have independent validation of the profiling data but we will also have determined the mechanism of altered expression of that gene. Furthermore, that particular gene will be more likely to have biological significance. Bioinformatics tools and biocomputational expertise are in place to harness the consistent and concordant molecular determinants in the oral SCC (Aim 3). This proposal optimally utilizes existing patient resources and emerging technologies to harness consistent and concordant genomic and transcriptional determinants in oral SCC. This will serve as a pilot project and/or feasibility test for more extensive patient-based studies to identify and validate molecular biomarkers for early detection of oral/head and neck cancer.

描述（由申请人提供）：口腔鳞状细胞癌（SCC）是全球第六大常见癌症，占男性癌症的4%和女性癌症的2%。在美国，每年有超过38000例口腔癌新病例。在过去几十年中，口腔癌的总体5年生存率一直很低，约为30-40%，并且仍然是所有癌症死亡率中最严重的。这令人失望，并指出需要制定预防、诊断和治疗这种疾病的新战略。