Multiscale mechanics: folded globular proteins as hydrogel Lego bricks

多尺度力学：折叠球状蛋白质作为水凝胶乐高积木

• 批准号: 2751760
• 金额: --
• 依托单位: University of Leeds
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2751760
• 关键词: Multiscale; mechanics; folded; globular; proteins

Mechanical properties are an essential property of biological scaffolds, where cell behaviour can be controlled by designing material scaffolds that incorporate specific structural and mechanical cues.Proteins are semi-flexible polymer and biopolymer networks formed by semi-flexible polymers have emerged as a new class of biological soft matter systems with remarkable material properties, motivating many theoretical developments. Such theories include the mechanics and dynamics of individual semiflexible polymers, bundles and entangled solutions and non-affine approaches for disordered polymer networks.The PGR will join a multidisciplinary team to understand the physics of the building block (the folded protein) and its connectivity (the protein network). This will be achieved through a cross length scale, physics based approach which will translate knowledge of the nanoscale biophysics of folded proteins to the mesoscale architecture and function of novel folded protein hydrogels. Experimental techniques will include rheology, scattering, microbubbles and ultrasound.

力学性能是生物支架的基本性能，通过设计具有特定结构和力学特征的材料支架可以控制细胞行为。蛋白质是半柔性聚合物，由半柔性聚合物形成的生物聚合物网络已成为一类新的生物软物质系统，具有显着的材料性能，推动了许多理论发展。这些理论包括单个半柔性聚合物的力学和动力学，束和纠缠解决方案以及无序聚合物网络的非仿射方法。PGR将加入一个多学科团队，了解构建模块（折叠蛋白质）及其连接性（蛋白质网络）的物理学。这将通过交叉长度尺度，基于物理学的方法来实现，该方法将折叠蛋白质的纳米级生物物理学知识转化为新型折叠蛋白质水凝胶的介观结构和功能。实验技术将包括流变学，散射，微泡和超声。