Antigen presentation to T cells in nonlymphoid tissue

抗原呈递给非淋巴组织中的 T 细胞

• 批准号: 7054953
• 负责人: James B McLachlan
• 金额: $ 4.88万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7054953
• 关键词: antigen presentation; antigens; dendritic cells; tissues

DESCRIPTION (provided by applicant): It has been well established that antigen presentation in secondary lymphoid organs is essential for the initiation of an antigen specific adaptive immune response. The primary phase of this response consists of antigen presentation by dendritic cells in the context of MHC II where it is then recognized by CD4+ T cells which in turn can become activated. Activated effector CD4+ T cells migrate back into sites of antigen deposition where they can remain for weeks. This proposal seeks to determine the role of antigen presentation in nonlymphoid tissues with respect to its effect on CD4+ T cells. While we expect that the inflammatory milieu in the tissue initiates the entry of effector T cells equally, we hypothesize that in order for maximal accumulation, sequestration, and sustained activation to occur, antigen-specific T cells must recognize cognate antigen in the context of MHC II at the actual site of antigen deposition. Our hypothesis is that while dendritic cells activate T cells in the lymph nodes, macrophages in the tissue is responsible for antigen presentation at the site of antigen deposition and for the sustained activation and retention of CD4+ T cells.

描述（由申请人提供）：已经很好地确定，次级淋巴器官中的抗原表现对于启动抗原特异性适应性免疫反应至关重要。该响应的主要阶段由树突状细胞在MHC II的背景下由树突状细胞表现出来，然后由CD4+ T细胞识别出来，而CD4+ T细胞又可以被激活。活化的效应子CD4+ T细胞迁移回抗原沉积的部位，它们可以保留数周。该提案旨在确定抗原在非淋巴组织中对CD4+ T细胞的影响的作用。尽管我们期望组织中的炎症环境平均启动效应T细胞的进入，但我们假设，为了使最大的积累，隔离和持续激活发生，抗原特异性T细胞必须识别抗原沉积物的MHC II背景中的抗原抗原。我们的假设是，虽然树突状细胞激活淋巴结中的T细胞，但组织中的巨噬细胞负责在抗原沉积部位抗原表现以及CD4+ T细胞的持续激活和保留。