Photoactivatable molecular probes to study RNA-protein interactions

用于研究 RNA-蛋白质相互作用的光激活分子探针

• 批准号: 2753246
• 金额: --
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2753246
• 关键词: Photoactivatable; molecular; probes; study; RNA

Due to their rich structural diversity and broad range of biological functions, targeting RNA with small molecules is becoming an important strategy in drug discovery. Most cellular functions of RNA are controlled by proteins and dysregulation of these interactions can lead to a range of human diseases. Therefore, there is an increasing interest in efficient methods to identify proteins that bind to specific RNA structures. This project aims to develop a new class of molecular probe (based on small organic and/or metal-organic molecules) for the selective photolabeling of RNA-binding proteins. The new probes developed in this project will be applied to study repeat expansions in RNA structures, several of which are responsible for various neurological and neuromuscular diseases.

由于RNA具有丰富的结构多样性和广泛的生物学功能，小分子靶向RNA正成为药物开发的重要策略。RNA的大多数细胞功能是由蛋白质控制的，这些相互作用的失调可导致一系列人类疾病。因此，人们对识别结合特定RNA结构的蛋白质的有效方法越来越感兴趣。本项目旨在开发一种新型分子探针（基于小有机和/或金属有机分子），用于rna结合蛋白的选择性光标记。该项目开发的新探针将用于研究RNA结构中的重复扩增，其中一些是导致各种神经和神经肌肉疾病的原因。