New Classes of Electron Paramagnetic Resonance Imaging Probes With High-Spin Metal Complexes

具有高自旋金属配合物的新型电子顺磁共振成像探针

• 批准号: 10712009
• 负责人: Joseph M Zadrozny
• 金额: --
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10712009
• 关键词: Amendment; Anatomy; Chemicals; Chemistry; Dangerousness; Electron Spin Resonance Spectroscopy; Electronics; Electrons; Frequencies; Functional Imaging; Goals; Hybrids; Image; Inorganic Chemistry; Ions; Knowledge; Laboratories; Magnetic Resonance Imaging; Maps; Metals; Modernization; Molecular Probes; Physiological; Process; Property; Resolution; System; Techniques; Work; analog; biomedical imaging; body map; design; imaging probe; magnetic field; meetings; metal complex; microwave electromagnetic radiation; molecular imaging; non-invasive imaging

Project Summary/Abstract The focus of the Zadrozny laboratory is the design of metal complexes for noninvasive sensing of physiological chemistry. The broader goal of the effort is to make molecular probes that overcome inherent challenges in electron paramagnetic resonance imaging (EPRI), the unpaired electron analog to conventional 1H MRI. EPRI can sense local chemistry and could produce comprehensive chemical and anatomical maps of the body if merged with 1H MRI. Modern EPRI molecular imaging probes are organic radicals which require dangerous high-energy microwaves for use in the large magnetic field of an MRI scanner. Hence, the two techniques remain disconnected. For EPRI to enable imaging of physiological chemistry by integration with MRI, new probes must be developed to avoid high frequency microwaves at high magnetic fields. The next five years of the Zadrozny lab’s work involve exploring high-spin metal complexes as an alternative platform to radicals for molecular probes in EPRI. A key inherent advantage of metal ions is that the unique electronic feature of large zero-field splitting enables the possibility of safe, low-frequency microwave use at high magnetic field. Hence, metal complexes with this feature could provide a completely new set of EPRI molecular imaging probes with capabilities unmatched by organic radicals. However, all of the basic EPR spectral properties of metal complexes with low frequency microwaves are unmapped. The Zadrozny lab will amend this knowledge gap. The work will use synthetic inorganic chemistry and spectroscopic analyses to (1) understand how to target the frequency/field of the resonance to match the magnetic fields of MRI scanners with low-frequency microwaves (2) understand how to control the linewidth of the low-frequency EPR resonances to enhance resolution, and (3) how to merge radical/metal chemistry in hybrid molecules to gain the advantages of both metals and radicals for a single molecular probe system. Meeting these objectives will provide a new class of imaging probe capable of mapping physiological chemistry in a conventional MRI scanner.

项目总结/摘要 Zadrozny实验室的重点是设计用于非侵入式传感的金属络合物 生理化学。这项工作更广泛的目标是制造分子探针， 克服了电子顺磁共振成像（EPRI）的固有挑战， 电子模拟常规1H MRI。EPRI可以感知当地的化学物质， 如果与1H MRI合并，则可以获得身体的全面化学和解剖图。现代EPRI 分子成像探测器是需要危险的高能微波的有机自由基 用于MRI扫描仪的大磁场中。因此，这两种技术仍然存在 切断了.对于EPRI，通过与MRI集成实现生理化学成像，新 必须开发探针以避免在高磁场下的高频微波。下一 Zadrozny实验室五年的工作涉及探索高自旋金属络合物作为一种 EPRI分子探针自由基的替代平台。金属的一个关键固有优势 大的零场分裂的独特电子特征使得安全， 在高磁场下使用低频微波。因此，具有该特征的金属络合物 可以提供一套全新的EPRI分子成像探针， 有机自由基无法比拟。然而，金属的所有基本EPR光谱特性 具有低频微波的复合物未被绘制。扎德罗兹尼实验室会修改这个 知识差距。这项工作将使用合成无机化学和光谱分析， (1)了解如何将共振的频率/场作为目标，以匹配 使用低频微波的MRI扫描仪（2）了解如何控制 低频EPR共振，以提高分辨率，以及（3）如何合并自由基/金属 混合分子中的化学，以获得金属和自由基的优点， 分子探针系统满足这些目标将提供一类新的成像探头 能够在常规MRI扫描仪中绘制生理化学。