Functional dyspepsia: Characterisation of the immunopathology and testing a novel therapeutic strategy.

功能性消化不良：免疫病理学特征和测试新的治疗策略。

• 批准号: nhmrc : 1061004
• 负责人: Dr Natasha Koloski
• 金额: $ 49.32万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/functional-dyspepsia-characterisation-therapeutic-strategy/454862
• 关键词: Functional; dyspepsia; Characterisation; immunopathology; testing

Dyspepsia, unexplained stomach discomfort and pain, is a common and costly problem; few effective treatments exist and the causes are unknown. We have found that the numbers of a type of immune cell, the eosinophil, are increased in the top of the small bowel in patients with dyspepsia. This study will explore the mechanisms that lead to increased eosinophils and then test the effectiveness of a treatment to suppress this overactive immune response which could rapidly change clinical practice.

消化不良，即不明原因的胃部不适和疼痛，是一个常见且代价高昂的问题；几乎没有有效的治疗方法，而且原因尚不清楚。我们发现消化不良患者小肠顶部的一种免疫细胞——嗜酸性粒细胞的数量增加。这项研究将探索导致嗜酸性粒细胞增加的机制，然后测试抑制这种过度活跃的免疫反应的治疗效果，这可能会迅速改变临床实践。