A Natonal Resource for Postmortem Brain Research

死后大脑研究的国家资源

• 批准号: 7146275
• 负责人: FRANCINE M. BENES
• 金额: $ 26.64万
• 依托单位: MCLEAN HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-17 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7146275
• 关键词: Natonal; Resource; Postmortem; Brain; Research

DESCRIPTION (provided by applicant): The specific aims of the Harvard Brain Tissue Resource Center, HBTRC, RO1 grant are to 1) Acquire Postmortem Brains, 2) Process and Store Postmortem Brains and 3) Distribute Tissue and Information. This supplement is intended to provide support to the Autism Tissue Program (ATP) to expand and augment these three areas to promote the acquisition of brain tissue representing autism spectrum disorders into a main repository and to promote the most scientifically responsible use of the resource for biomedical research. To maximize brain tissue collection, the ATP makes those in the autism community aware of the need for brain tissue, explains exactly how to donate brain tissue, and how to obtain the necessary support for donation when involved in the crisis of a death. Second, the ATP has launched the MyATP project aimed at developing rapid autopsy for optimized brain tissue in several states. A recently expanded Tissue Advisory Board (TAB), comprised of accomplished scientists who are experienced in an array of tissue- related disciplines, is in place to review brain processing and storage methods that would allow for optimal use of autism tissue. Third, the TAB oversees the distribution of tissue to investigators after reviewing written applications for tissue and is charged with the responsibility of making recommendations regarding future research directions. In support of this third aim, the Autism Tissue Program maintains a database and website portal for researchers. The acquisition and examination of brain tissue is a necessary component of autism research providing a way for the direct study of brain cells, of neurotransmitter systems and of gene expression for signs of developmental changes, to identify biomarkers for diagnosis and to suggest potential treatments.

描述（由申请人提供）：哈佛大学脑组织资源中心，HBTRC，RO1授予的特定目的是1）获取后大脑，2）过程和储存后大脑和3）分配组织和信息。该补充旨在为自闭症组织计划（ATP）提供支持，以扩大和增强这三个领域，以促进代表自闭症谱系障碍的脑组织的获取，并促进对生物医学研究的最科学负责的资源使用。为了最大程度地收集脑组织，ATP使自闭症社区中的人们意识到对脑组织的需求，确切地解释了如何捐赠脑组织，以及在涉及死亡危机时如何获得捐赠的必要支持。其次，ATP启动了MYATP项目，旨在开发快速尸检以在几个州进行优化的脑组织。最近扩展的组织咨询委员会（TAB），由在组织相关学科中经验丰富的经验丰富的科学家组成，可以审查大脑加工和储存方法，这些方法允许最佳使用自闭症组织。第三，该标签在审查了组织的书面申请后，监督组织向研究人员的分布，并负责就未来的研究方向提出建议。为了支持第三个目标，自闭症组织计划为研究人员维护数据库和网站门户。对脑组织的获取和检查是自闭症研究的必要组成部分，为直接研究脑细胞，神经递质系统和基因表达的直接研究提供了一种方法，以识别用于诊断的生物标志物并建议潜在治疗。