Confocal Imaging for Neuropsychiatric Research

用于神经精神病学研究的共焦成像

• 批准号: 8247451
• 负责人: FRANCINE M. BENES
• 金额: $ 36.97万
• 依托单位: MCLEAN HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-03 至 2013-09-02
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8247451
• 关键词: Anxiety Disorders; Award; Body Image; Cognition; Complex; Development; Disease; Electron Microscope; Emotions; Ensure; Equipment; Funding; Grant; Hospitals; Image; Maintenance; Microscope; Molecular; Mood Disorders; Neurodegenerative Disorders; Neurons; Patients; Psychotic Disorders; Research; Research Personnel; Stress; Time; United States National Institutes of Health; Work; instrument; instrumentation; neural circuit; neuropsychiatry; programs; translational study

DESCRIPTION (provided by applicant): The Mailman Research Center (MRC) at McLean Hospital is a critical component to our translational studies of the causes and treatments of neuropsychiatric disorders. The MRC Imaging Facility must replace our outmoded Leica confocal microscope with a state-of-the-art instrument. This will enhance our ability to perform co- localization studies of cellular and molecular mechanisms within neuronal subpopulations that regulate complex neural circuits involved in emotion and cognition. Ongoing work in the MRC focuses on corticolimbic circuits believed to be dysfunctional in patients with major psychoses, mood and anxiety disorders, post-traumatic stress, development disorders and neurodegenerative diseases. This proposal describes the need for a Leica TCS SP5 confocal microscope. This instrument will provide MRC investigators with a broad array of imaging capabilities. We currently have JEOL 1200EX electron microscope and a Leica confocal microscope; both were purchased with funds awarded through two separate NIH Shared Instrumentation Grants. In 1985, when the EM was procured, we established a Users Committee and this has served as a governing body for the Imaging Facility since that time. If this application is successful, our Users Committee will coordinate the use and maintenance of the new confocal microscope. Since 1985, a financial plan for the support of our Imaging Facility has been in place and will be amended to cover the new instrumentation. Historically, McLean Hospital has provided additional support for this facility and will continue to do so. The procurement of the proposed equipment will ensure that the MRC at McLean Hospital will be able to maintain a "cutting edge" research program for the study of neuropsychiatric disorders. PUBLIC HEALTH RELEVANCE: McLean Hospital has a multidisciplinary research program directed at the study of psychosis, mood and anxiety disorders, post-traumatic stress, development disorders and neurodegenerative diseases. The productivity of this program is dependent upon the availability of state-of-the-art imaging technology for visualizing neuronal circuitry both structurally and functionally. This proposal describes our need for a new sophisticated confocal imaging instrument that will allow us to function at the "cutting edge" of psychiatric neuroscience where it will be possible to develop innovative new approaches to the treatment of neuropsychiatric disorders.

描述（由申请人提供）：麦克莱恩医院的邮递员研究中心（MRC）是我们对神经精神疾病的原因和治疗的翻译研究的关键部分。 MRC成像设施必须用最先进的仪器代替我们过时的Leica共聚焦显微镜。 这将增强我们对神经元亚群中细胞和分子机制进行共同定位研究的能力，从而调节与情绪和认知有关的复杂神经回路。 MRC中正在进行的工作集中于患有主要精神病，情绪和焦虑症，创伤后压力，发育障碍和神经退行性疾病的患者中据信的皮质唇电路。 该建议描述了对Leica TCS SP5共聚焦显微镜的需求。 该仪器将为MRC调查人员提供广泛的成像功能。 目前，我们有JEOL 1200EX电子显微镜和Leica共聚焦显微镜；两者都是通过两种独立的NIH共享仪器赠款授予的资金购买的。 1985年，当收购EM时，我们成立了一个用户委员会，从那时起，这一直是成像设施的管理机构。 如果此应用程序成功，我们的用户委员会将协调新共聚焦显微镜的使用和维护。 自1985年以来，已经建立了一项支持我们成像设施的财务计划，并将进行修改以覆盖新的仪器。 从历史上看，麦克莱恩医院为该设施提供了额外的支持，并将继续这样做。 拟议设备的采购将确保麦克莱恩医院的MRC能够维护“尖端”研究计划，以研究神经精神疾病。 公共卫生相关性：麦克莱恩医院（McLean Hospital）拥有一项多学科研究计划，致力于研究精神病，情绪和焦虑症，创伤后压力，发育障碍和神经退行性疾病。该程序的生产力取决于最先进的成像技术，用于在结构和功能上可视化神经元电路。该建议描述了我们需要一种新的复杂共聚焦成像工具，该工具将使我们能够在精神神经科学的“最前沿”发挥作用，在那里可以开发创新的新方法来治疗神经精神疾病。