Cincinnati DDRDC: Center for Growth and Development (CG*

总体描述(由申请人提供)： 辛辛那提DDRDC：生长与发展中心(CGD)的总体目标是促进研究，深入了解消化道生长和发育的基本过程，并导致新的或改进的治疗方法。CGD的具体目标源于一个中心主题，即了解控制胃肠道和肝脏发育的分子机制将导致纠正肠道、营养和肝脏疾病的策略。此外，我们跨学科协作的工作模式和我们强大的研究环境将继续导致消化系统疾病的富有成效的研究。28名正式成员和6名准成员来自小儿科的9个不同部门和辛辛那提大学医学院的6个部门。这些研究人员被分成四个影响生长和发育的工作领域：分化、吸收和分泌、炎症以及再生和修复。辛辛那提DDRDC：CGD的目标是：1)通过研究分化、吸收和分泌、炎症以及再生和修复，促进与了解胃肠道和肝脏生长发育以及消化系统疾病相关的基础科学和翻译科学领域的研究；2)促进不同背景的科学家之间的互动；3)吸引基础研究人员研究胃肠和肝脏生长和发育；以及4)促进消化系统疾病的翻译研究。中心的具体目标将主要通过三个相互关联的生物医学研究中心来实现。1)微阵列核心将进行高质量的最先进的实验，以确定在人类消化器官和疾病动物模型中表达的新基因。2)生物信息学核心将为在微阵列核心中进行的复杂实验提供设计协助以及统计和计算分析。3)综合形态核心将为形态研究提供咨询和技术支持，包括原位杂交，以定位微阵列分析确定的基因表达。因此，在许多层面上，研究基础之间和生物医学研究核心之间存在着很强的协同作用。这种协同效应将提高效率，推动新的研究方向，并促进合作。

DESCRIPTION, OVERALL (provided by applicant): The overall goal of the Cincinnati DDRDC: Center for Growth and Development (CGD) is to promote research that will yield insights into the fundamental processes of growth and development in the digestive tract and lead to novel or improved therapies. The specific goals of the CGD derive from the central theme that understanding the molecular mechanisms that control development of the gastrointestinal tract and liver will result in strategies to correct intestinal, nutritional and liver disease. Furthermore, our working model of interdisciplinary collaboration and our strong research environment will continue to lead to productive investigation in digestive diseases. The 28 full members and 6 associate members come from 9 different divisions within the Department of Pediatrics and a total of 6 Departments within the University of Cincinnati College of Medicine. These investigators are grouped into four working areas that all impact growth and development: Differentiation, Absorption and Secretion, Inflammation, and Regeneration and Repair. The Aims of the Cincinnati DDRDC:CGD are: 1) To promote research in basic and translational science areas relevant to understanding of gastrointestinal and liver growth and development, as well as digestive disease, by studying differentiation, absorption and secretion, inflammation, and regeneration and repair; 2) To promote interactions among scientists with diverse backgrounds, 3) To attract basic investigators to the study of gastrointestinal and liver growth and development, and 4) To foster translational research in digestive disease. The specific aims of the Center will be achieved primarily through three inter-related Biomedical Research Cores. 1) The Microarray Core will perform high quality state of the art experiments to identify novel genes expressed in the digestive organs of humans and in animal models of disease. 2) The Bioinformatics Core will provide design assistance and statistical and computational analysis for the complex experiments performed in the Microarray Core. 3) The Integrative Morphology Core will provide consultation and technical support for morphology studies, including in situ hybridization to localize gene expression identified by microarray analysis. Thus, at many levels, there is strong synergy among the research base and among the Biomedical Research Cores. This synergy will increase efficiency, promote new research directions, and foster collaborations.