Versatile annotation and publication quality visualization of protein complexes using POLYVIEW-3D.
Versatile annotation and publication quality visualization of protein complexes using POLYVIEW-3D.
复制标题
使用PolyView-3D对蛋白质复合物的多功能注释和出版质量可视化。
DOI：
10.1186/1471-2105-8-316
复制
发表时间：
2007-08-29
影响因子：
3
通讯作者：
Meller J
中科院分区：
文献类型：
--
作者：
Porollo A;Meller J
在基因组后时代，大分子可视化以及自动化的结构和功能注释工具发挥着日益重要的作用，对理解分子系统和过程有重大贡献。例如，三维（3D）模型有助于探索蛋白质活性位点和药物设计中可作为靶点的功能热点。自动化注释和可视化流程也能够揭示大分子的其他重要功能属性。这些目标依赖于先进工具的可用性，这些工具能更好地将现有数据库、注释服务器和其他资源与最先进的渲染程序整合在一起。
我们介绍一种用于蛋白质结构分析的新工具，重点是蛋白质复合物的注释和可视化，它是我们之前开发的POLYVIEW网络服务器的扩展。通过将网络技术与用于大分子可视化的先进软件（如PyMol程序）相结合，POLYVIEW - 3D能够将多种结构和功能注释与一个简单的基于网络的界面相结合，用于创建可用于出版的高质量结构渲染图，以及用于Powerpoint™、网站和其他电子资源的动画图像。该服务与平台无关，不需要插件。文中给出了几个关于POLYVIEW - 3D如何在蛋白质 - 蛋白质相互作用的背景下用于结构和功能分析的例子，以说明可用的注释选项。
POLYVIEW - 3D服务器具有PyMol图像渲染功能，它通过一个易于使用的基于网络的界面，提供大分子结构的详细和高质量呈现。POLYVIEW - 3D还为蛋白质及其复合物的自动化结构和功能分析提供了广泛的选项。因此，POLYVIEW - 3D服务器可能会成为蛋白质科学和结构生物信息学领域研究人员和教育工作者的重要资源。新服务器可在[具体网址未给出]获取。
Macromolecular visualization as well as automated structural and functional annotation tools play an increasingly important role in the post-genomic era, contributing significantly towards the understanding of molecular systems and processes. For example, three dimensional (3D) models help in exploring protein active sites and functional hot spots that can be targeted in drug design. Automated annotation and visualization pipelines can also reveal other functionally important attributes of macromolecules. These goals are dependent on the availability of advanced tools that integrate better the existing databases, annotation servers and other resources with state-of-the-art rendering programs. We present a new tool for protein structure analysis, with the focus on annotation and visualization of protein complexes, which is an extension of our previously developed POLYVIEW web server. By integrating the web technology with state-of-the-art software for macromolecular visualization, such as the PyMol program, POLYVIEW-3D enables combining versatile structural and functional annotations with a simple web-based interface for creating publication quality structure rendering, as well as animated images for Powerpoint™, web sites and other electronic resources. The service is platform independent and no plug-ins are required. Several examples of how POLYVIEW-3D can be used for structural and functional analysis in the context of protein-protein interactions are presented to illustrate the available annotation options. POLYVIEW-3D server features the PyMol image rendering that provides detailed and high quality presentation of macromolecular structures, with an easy to use web-based interface. POLYVIEW-3D also provides a wide array of options for automated structural and functional analysis of proteins and their complexes. Thus, the POLYVIEW-3D server may become an important resource for researches and educators in the fields of protein science and structural bioinformatics. The new server is available at .
登录
查看更多内容
影响因子：
5.8
作者：
Glaser, F;Pupko, T;Ben-Tal, N
通讯作者：
Ben-Tal, N
Pfam：氏族、网络工具和服务。
影响因子：
14.9
作者：
Finn, Robert D.;Mistry, Jaina;Schuster-Bockler, Benjamin;Griffiths-Jones, Sam;Hollich, Volker;Lassmann, Timo;Moxon, Simon;Marshall, Mhairi;Khanna, Ajay;Durbin, Richard;Eddy, Sean R.;Sonnhammer, Erik L. L.;Bateman, Alex
通讯作者：
Bateman, Alex
aismig - 交互式服务器端分子图像发生器。
影响因子：
14.9
作者：
Bohne-Lang A;Groch WD;Ranzinger R
通讯作者：
Ranzinger R
影响因子：
14.9
作者：
Binisti, C;Salim, AA;Tufféry, P
通讯作者：
Tufféry, P
影响因子：
14.9
作者：
Maiti, R;Van Domselaar, GH;Wishart, DS
通讯作者：
Wishart, DS