X-Ray Detector for the Life Sciences CAT at the APS

APS 生命科学 CAT 的 X 射线探测器

• 批准号: 6877407
• 负责人: WAYNE F ANDERSON
• 金额: $ 50万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-15 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6877407
• 关键词: biomedical equipment purchase; computed axial tomography; electron crystallography; structural biology

DESCRIPTION (provided by applicant): This proposal requests funds for acquiring state of the art instrumentation for structural biology research on the initial insertion device beamline in the Life Sciences (LS-CAT) sector at the Advanced Photon Source. This beamline will utilize radiation from the first of two (2) undulators that LS-CAT will install and will provide a tunable, high intensity beamline for macromolecular crystallography. Funds for the Phase I construction, which includes this beamline, have already been obtained by LS-CAT and construction is about to begin. It is expected that first use of the beamline will occur in late 2005. The Life Sciences Collaborative Access Team is a consortium of academic and research institutions comprised of Northwestern University, Michigan State University, the University of Michigan, Wayne State University, the Van Andel Institute, the University of Illinois at Urbana-Champaign, and the University of Wisconsin. The investigators participating in LS-CAT are involved in cutting edge structural biology with special emphasis in membrane proteins, multicomponent systems in signaling and protein transport, protein-nucleic acid complexes involved in genome replication, repair, recombination and regulation, and enzymes that are novel targets for mechanistic studies or biotechnology. Many of the researchers associated with LS-CAT have already reached the technical barriers of small crystal size or large unit cells that make access to a dedicated synchrotron source essential to the scientific progress. The instrumentation requested is a large area CCD detector suitable for high resolution studies of individual macromolecules and complexes with large unit cells. The requested detector will have the large surface area, high spatial resolution and rapid read-out that are essential for allowing investigators to tackle increasingly difficult structural problems.

描述（由申请人提供）：该提案要求提供资金，用于在高级光子源的生命科学（LS-CAT）部门的初始插入装置光束线上进行结构生物学研究的最先进仪器。该光束线将利用LS-CAT将安装的两（2）个波荡器中的第一个的辐射，并将为大分子晶体学提供可调谐的高强度光束线。LS-CAT已经获得了包括这条光束线在内的第一阶段建设的资金，建设即将开始。预计2005年底将首次使用光束线。生命科学协作获取团队是一个学术和研究机构联盟，由西北大学、密歇根州立大学、密歇根大学、韦恩州立大学、货车安德尔研究所、伊利诺伊大学厄巴纳-香槟分校和威斯康星州大学组成。参与LS-CAT的研究人员涉及前沿结构生物学，特别强调膜蛋白、信号传导和蛋白质转运中的多组分系统、参与基因组复制、修复、重组和调节的蛋白质-核酸复合物，以及作为机制研究或生物技术新靶点的酶。许多与LS-CAT相关的研究人员已经达到了小晶体尺寸或大晶胞的技术障碍，这使得获得专用同步加速器源对科学进步至关重要。所要求的仪器是一个大面积的CCD检测器，适用于高分辨率的研究，个别大分子和复杂的大单位细胞。所要求的探测器将具有大表面积、高空间分辨率和快速读出，这对于使调查人员能够解决日益困难的结构问题至关重要。