Zimbabwe: Community Intervention to Reduce HIV/STD Risk

津巴布韦：社区干预降低艾滋病毒/性病风险

• 批准号: 7123436
• 负责人: Danuta Kasprzyk
• 金额: $ 175.53万
• 依托单位: BATTELLE CENTERS/PUB HLTH RES & EVALUATN
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-30 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7123436
• 关键词: AIDS education /prevention; Africa; HIV infections; Trichomonas; behavioral /social science research tag; chlamydial disease; clinical research; clinical trials; communicable disease control; community; community health services; cooperative study; culture; education evaluation /planning; gonorrhea; health care service utilization; health services research tag; high risk behavior /lifestyle; human subject; human therapy evaluation; international cooperation; longitudinal human study; patient oriented research; public opinion; safe sex /sex abstinence; sex behavior; sex education; sexually transmitted diseases; substance abuse related behavior; syphilis; young adult human (21-34)

DESCRIPTION (provided by applicant): The NIMH Collaborative HIV/STD Prevention Trial is a two-arm randomized, community-level trial being conducted in five countries -- China, India, Peru, Russia, and Zimbabwe. It is the first international test of a community-level prevention program based on the theory of diffusion of innovations utilizing Community Public Opinion Leaders (C-POLs). Based on a set of ethnographic studies conducted over 18 months and a series of epidemiological studies with over 9000 participants in the five countries, an assessment and the C-POL intervention have been culturally adapted, piloted and mounted in randomly chosen venues in each country. The intervention's efficacy in reducing self-reported behavioral risk with non-spousal partners and incident sexually transmitted diseases is being assessed based on a baseline, 2- and 24- month interviews and collection of biological specimens. After conducting the 24 month assessment, the intervention will be provided in the comparison venues. This proposal requests three years of funding to complete the randomized controlled trial in each site; the extended period is requested because of the extra time required at the initiation of the study to conduct multiple epidemiological and ethnographic studies to ensure cross-site comparability and within site validity to all assessments, intervention, and data collection and reporting processes. The results of this trial should provide the first documentation and evaluation of the portability and adaptability of interventions cross-nationally and cross-culturally and is being designed and implemented to be realistic and feasible for replication and dissemination. The AIDS epidemic in Zimbabwe is a generalized epidemic with one in four individuals infected. In spite of HIV prevention efforts carried out consistently over the last ten years, the epidemic has not leveled off (UNAIDS, 2003). Most governmental and NGO prevention efforts have been focused on increasing knowledge. A community level approach, to create normative changes using the C-POL model has not been tried in this country with a generalized epidemic. This trial allows the first test of a community level intervention to encourage behavior change in Zimbabwe. If s If successful, the intervention will be disseminated widely in Zimbabwe.

描述（由申请人提供）：NIMH艾滋病/性病预防合作试验是一项在中国、印度、秘鲁、俄罗斯和津巴布韦五个国家进行的两组随机、社区水平的试验。这是基于利用社区公众意见领袖（C-POLs）的创新扩散理论的社区一级预防项目的第一个国际测试。根据在这五个国家进行的为期18个月的一套人种学研究和对9000多名参与者进行的一系列流行病学研究，在每个国家随机选择的地点进行了文化调整、试点和实施了评估和C-POL干预措施。根据基线、2个月和24个月的访谈和收集的生物标本，正在评估干预措施在减少与非配偶伴侣的自我报告行为风险和偶发性传播疾病方面的功效。在完成为期24个月的评估后，将在比较场地提供干预措施。

项目成果

Concurrent partnerships, acute infection and HIV epidemic dynamics among young adults in Zimbabwe.

• DOI: 10.1007/s10461-010-9858-x
• 发表时间: 2012-02
• 期刊: AIDS AND BEHAVIOR
• 影响因子: 4.4
• 作者: Goodreau, Steven M.;Cassels, Susan;Kasprzyk, Danuta;Montano, Daniel E.;Greek, April;Morris, Martina
• 通讯作者: Morris, Martina