Recruitment and Assessment Core Patient Recruitment

CCNMD的招聘和评估（R&A）核心目标是支持所有 中心的项目。R&A有七个主要目标：1）实施功能良好的筛选， CCNMD项目的招募和评估流程; 2）招募老年人和年轻人（> 60岁） 每年符合CCNMD项目入选标准的患者; 3）招募和筛选正常， CCNMD项目需要年龄匹配的年轻志愿者; 4）保持质量控制 系统监控评估核心人员工作的可靠性; 5）进行标准化MRI 用于患者评估的研究和收集用于遗传分析的血液; 6）将患者分配至 不同的项目，并确保没有不必要的负担，对受试者;和7）制定和 保持尸检资源 R&A核心将主要通过训练有素的关键人员和研究人员来实现这些目标， 包括研究精神病学家，神经心理学家，研究助理，神经心理学 技术员、神经病理学家和尸检协调员。受试者将接受全面的 精神病评估，医疗评估，详细审查心血管和 脑血管危险因素、标准化神经系统检查和标准化认知功能检查。 评估包括全面的神经心理测试电池。 患者将通过各种来源招募，包括杜克大学的不耐烦服务和一个 州立医院、杜克附属诊所、杜克ECT服务、临床试验和NIMH赞助的 抑郁症的自然纵向研究。将通过老化试验获得老年对照品。 老年志愿者中心登记处。将通过类似的数据库招募年轻对照。 R&A工作人员将努力确保所有受试者都完成了CCNMD方案。R&A工作人员将 为抑郁症受试者找到适当的随访，无论是通过转诊还是在其他 调查研究。

The objective of this Recruitment and Assessment (R&A) Core for the CCNMD is to support all of the Center's projects. There are seven main aims of R&A: 1) To implement a well functioning screening, recruitment and assessment process for CCNMD projects; 2) To recruit elderly and young (> 60 yrs) patients meeting entry criteria per year for CCNMD projects; 3) To recruit and screen the normal, age-matched and young volunteers required for CCNMD projects; 4) To maintain a quality control system to monitor the work of the assessment core staff for reliability; 5) To conduct standardized MRI studies for patient assessment and to collect blood for genetic analyses; 6) Allocation of patients to different projects and ensuring that there is no undue burden on subjects; and 7) To develop and maintain an autopsy resource. The R&A Core will meet these goals chiefly through highly trained key personnel and research staff, including research psychiatrists, neuropsychologist, research assistants, a neuropsychological technician, a neuropathologist, and an Autopsy Coordinator. Subjects will receive a thorough psychiatric assessment, medical assessment, a detailed review of cardiovascular and cerebrovascular risk factors, standardized neurological examination, and a standardized cognitive assessment including a comprehensive neuropsychological test battery. Patients will be recruited through a variety of sources, including the impatient service at Duke and a state hospital, Duke affiliated clinics, the Duke ECT services, clinical trials, and an NIMH-sponsored naturalistic longitudinal study of depression. Elderly controls will be obtained through an Aging Center Registry of elderly volunteers. Young controls will be recruited through a similar data base. The R&A staff will work to ensure that all subjects have completed CCNMD protocols. R&A staff will find appropriate follow-up for depressed subjects, either through referral or enrollment in other research studies.