Midcareer Investigator Award in Geriatric Depression

老年抑郁症职业中期研究员奖

• 批准号: 8393505
• 负责人: DAVID C. STEFFENS
• 金额: $ 17.88万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8393505
• 关键词: Academic Medical Centers; Address; Aging; Alleles; American; Apolipoprotein E; Area; Award; Blood Vessels; Brain; Brain scan; Cerebrovascular Disorders; Clinical; Cognitive; Data; Dementia; Depressed mood; Development; Educational process of instructing; Elderly; Faculty; Funding; Genes; Genetic; Genetic Polymorphism; Geriatric Psychiatry; Grant; Head; Health; Hippocampus (Brain); Impaired cognition; Incidence; Individual; Long-Term Depression; Magnetic Resonance Imaging; Medical Students; Medicine; Mental Depression; Mental Health; Mental disorders; Mentors; Mid-Career Clinical Scientist Award (K24); Moods; Morphology; National Institute of Mental Health; Neurofibrillary Tangles; Neurosciences; Outcome; Pathology; Patients; Population; Positioning Attribute; Postdoctoral Fellow; Principal Investigator; Psychiatry; Public Health; Qualifying; Research; Research Personnel; Research Training; Risk; Role; Scholarship; Senile Plaques; Social support; Source; Time; Training; Training Programs; White Matter Disease; career; cerebrovascular; density; experience; folic acid metabolism; frontal lobe; functional status; geriatric depression; geriatric mental health; graduate student; interest; mild cognitive impairment; mind control; mortality; neuroimaging; neuropsychological; next generation; older patient; patient oriented research; pre-doctoral; professor; receptor; social

DESCRIPTION (provided by applicant): This is a competing renewal application for a K24 Career Award in Patient-Oriented Research. The candidate, Dr. David Steffens, is Professor of Psychiatry and Medicine at Duke University Medical Center, where he serves as the Head of the Division of Geriatric Psychiatry and Director of an NIMH-sponsored T32 Research Training Program. Dr. Steffens has established a record of scholarship in the area of geriatric depression, and he serves as Principal Investigator on two large NIMH-funded grants, an R01 focusing on longitudinal geriatric depression outcomes and on the Recruitment Core of a Conte Neuroscience Center studying cerebrovascular disease in late-life depression. He is the previous recipient of a Clinical Geriatric Mental Health Academic Award (K07). Dr. Steffens has mentored individuals at all levels, including undergraduates, graduate students, medical students, pre- and post-doctoral research fellows, psychiatry residents, geriatric psychiatry fellows, and junior faculty. These experiences make the candidate well qualified for this K24 Award. Through this Award, the candidate will expand his research by focusing on genes related to folate metabolism in late life depression. Using his funded research as a source for teaching, the candidate will be well positioned to mentor pre-doctoral and post-doctoral fellows as well as junior faculty. Under the Award, the candidate will spend at least 50% of his time conducting patient-oriented research and mentoring.

描述(由申请人提供)：这是一份竞争续签申请，以患者为中心的研究K24职业奖。候选人David Steffens博士是杜克大学医学中心的精神病学和医学教授，在那里他担任老年精神病学部门的负责人和NIMH赞助的T32研究培训项目的主任。斯蒂芬斯博士在老年抑郁症领域建立了学术记录，他是NIMH资助的两项大型拨款的首席研究员，一项是专注于纵向老年抑郁症结果的R01，另一项是康特神经科学中心的招募核心，该中心研究老年抑郁症中的脑血管疾病。他之前是临床老年精神卫生学术奖(K07)的获得者。斯蒂芬斯博士曾指导过各个层次的个人，包括本科生、研究生、医学生、博士后和博士后研究员、精神病学住院医师、老年精神病学研究员和初级教员。这些经历使候选人非常有资格获得这个K24奖。通过这个奖项，候选人将通过关注与晚年抑郁症叶酸代谢相关的基因来扩大他的研究范围。利用他资助的研究作为教学来源，候选人将很好地指导博士后和博士后研究员以及初级教师。根据该奖项，候选人将花费至少50%的时间进行以患者为导向的研究和指导。

项目成果

Cognitive impairment and depression outcomes in the IMPACT study.

• DOI: 10.1097/01.jgp.0000194646.65031.3f
• 发表时间: 2006-05
• 期刊: The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
• 作者: D. Steffens;M. Snowden;Ming‐Yu Fan;H. Hendrie;W. Katon;J. Unützer

Efficacy and safety of adjunctive aripiprazole in major depressive disorder in older patients: a pooled subpopulation analysis.

辅助阿立哌唑治疗老年重度抑郁症的疗效和安全性：亚群汇总分析。

• DOI: 10.1002/gps.2564
• 发表时间: 2011
• 期刊: International journal of geriatric psychiatry
• 影响因子: 4
• 作者: Steffens,DavidC;Nelson,JCraig;Eudicone,JamesM;Andersson,Candace;Yang,Huyuan;Tran,Quynh-Van;Forbes,RobertA;Carlson,BeritX;Berman,RobertM
• 通讯作者: Berman,RobertM

Exercise for late-life depression? It depends.

锻炼可以治疗晚年抑郁症吗？

• DOI: 10.1016/s0140-6736(13)60860-0
• 发表时间: 2013
• 期刊: Lancet (London, England)
• 作者: Steffens,DavidC

Influence of the number and severity of somatic symptoms on the severity of depression and suicidality in community-dwelling elders.

• DOI: 10.1111/appy.12138
• 发表时间: 2014-09
• 期刊: Asia-Pacific psychiatry : official journal of the Pacific Rim College of Psychiatrists
• 作者: Jeong HG;Han C;Park MH;Ryu SH;Pae CU;Lee JY;Kim SH;Steffens DC
• 通讯作者: Steffens DC

Structural brain changes as biomarkers and outcome predictors in patients with late-life depression: a cross-sectional and prospective study.

结构性大脑随着生物标志物和晚期抑郁症患者的结果预测因子而变化：一项横断面和前瞻性研究。

• DOI: 10.1371/journal.pone.0080049
• 发表时间: 2013
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Ribeiz SR;Duran F;Oliveira MC;Bezerra D;Castro CC;Steffens DC;Busatto Filho G;Bottino CM
• 通讯作者: Bottino CM