Translational Research to Enhance Cognitive Control

增强认知控制的转化研究

• 批准号: 7128070
• 负责人: James McCracken
• 金额: $ 16.98万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7128070
• 关键词: Tourette' s syndrome; adolescence (12-20); behavior therapy; children; clinical research; clinical trials; cognition; electroencephalography; functional magnetic resonance imaging; human subject; human therapy evaluation; longitudinal human study; mental disorder diagnosis; neuroimaging; short term memory; stimulus /response

Chronic Tic Disorder, including Tourette Syndrome, (CTD) is a relatively common and typically impairing neurodevelopmental disorder of childhood. CTD is associated with deficits in cogntive control, including working memory and response inhibition, and dysfunction of cortico-striatal circuits. Although medications targeting these circuits have been moderately effective in reducing CTD symptoms, Habit Reversal Training (HRT), a behavioral technique, has shown efficacy in providing durable symptom relief without the serious side effects associated with pharmacotherapy. This project aims to clarify the functional anatomy of key circuits subserving cognitive control in youngsters with CTD, to examine hypothesized mechanisms of cognitive enhancement associated with HRT, and to compare these mechanisms to those identified for medication treatment of ADHD. Determining the neural basis of behavioral interventions, such as HRT, and establishing the generalizability of these findings, has the potential to significantly enhance development of improved treatment strategies for CTD, including the development of optimal treatment regimes for individual patients. As such, the aims are highly consistent with the overal goals of the CIDAR. A total of 60 youngsters (aged 7-16) with a DSM-IV Chronic Tic Disorder will receive eight weeks of HRT using a manualized treatment protocol developed and previously tested by our group. Youngsters will also undergo comprehensive clinical, cognitive/EEG, and fMRI evaluation at baseline and post-treatment. A reduced clinical and cognitive/EEG battery will also be collected mid-treatment and three month follow-up (responders only) to examine course and durability of response. All participants will be initially recruited and screened by the Research Assessment Unit (RAU) which will also recruit a matched sample of normal controls to allow for baseline clinical, EEG/fMRI comparison with the CTD and Project III ADHD patient samples. The fMRI and EEG/Cognitive components of the study will be executed through close collaboration with the Imaging and Research Methods (RMC) Cores, respectively. Finally, treatment-related findings from this project will be systematically compared to those from Project III in order to document the potential commonality of neural mechanisms of treatment response across multiple disorders and treatment modalities.

慢性抽动障碍，包括图雷特综合征，（CTD）是一个相对常见的，通常会损害 儿童时期神经发育障碍。 CTD与同源控制中的缺陷有关，包括 工作记忆和响应抑制以及皮质 - 纹状体电路功能障碍。虽然药物 针对这些电路已经适度地有效地减少CTD症状，习惯逆转训练 （HRT）是一种行为技术，在不严重的情况下提供了持久症状的功效 与药物治疗相关的副作用。该项目旨在阐明功能 关键电路的解剖结构在患有CTD的年轻人的认知控制下，以检查假设 与HRT相关的认知增强机制，并将这些机制进行比较 确定用于多动症的药物治疗。确定行为的神经基础 干预措施（例如HRT）以及确定这些发现的普遍性，有可能 显着增强了改进的CTD治疗策略的发展，包括开发 个别患者的最佳治疗方案。因此，目标与 CIDAR的过度目标。 DSM-IV慢性疾病的总共60名年轻人（7-16岁）将 使用我们的手动治疗方案进行八周的HRT，以前由我们的 团体。年轻人还将在基线时进行全面的临床，认知/脑电图和fMRI评估 和治疗后。还将收集降低的临床和认知/脑电图电池， 三个月的随访（仅响应者）检查响应的课程和持久性。 所有参与者最初将由 研究评估单位（RAU）还将招募匹配的正常对照样本以允许 基线临床，EEG/FMRI与CTD和项目III ADHD患者样品进行了比较。 fMRI和 研究的脑电图/认知成分将通过与成像和成像的密切合作执行 研究方法（RMC）核心。最后，该项目与治疗相关的发现将是 与项目III的系统进行比较，以记录神经的潜在共性 多种疾病和治疗方式的治疗反应机制。