A Method for the Alkylation of Alcohols and Amines

醇和胺的烷基化方法

• 批准号: 7157188
• 负责人: Seth B. Herzon
• 金额: $ 4.4万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-14 至 2009-08-13
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7157188
• 关键词: alcohols; aldehydes; alkaloids; alkenes; alkylation; amines; biological products; chemical conjugate; chemical synthesis; combinatorial chemistry; imines; indoles; method development; plants; postdoctoral investigator; stereochemistry; stereoisomer

DESCRIPTION (provided by applicant): This goal of this research is the development of a new method for the stereocontrolled synthesis of secondary alcohols, acylic aliphatic amines, 1,2-diols, 1,2-amino alcohols, and 1,2-diamines. Such motifs are found in compounds of biological and medicinal importance, the drugs Taxol, vancomycin, and indinivar being notable examples. The method will allow for the formation of these compounds directly from primary alcohols and acylic aliphatic amines, starting materials which are abundant and widely accesible. It is envisioned that the technologies developed in this program will find use in the synthesis of natural and unnatural therapeutic agents; this will be demonstrated by the application of these methods to the total synthesis of the Strychnos alkaloid (-)-dehydrotubifoline. A portion of the research will examine the development of asymmetric C-H bond activation processes, an area of chemistry which is still largely unexplored.

描述（由申请人提供）：本研究的目标是开发一种立体控制合成仲醇、酰基脂肪胺、1,2-二醇、1,2-氨基醇和1,2-二胺的新方法。这些基序存在于具有重要生物学和医学意义的化合物中，如紫杉醇、万古霉素和茚地伐就是显著的例子。该方法将允许直接从伯醇和酰基脂肪胺形成这些化合物，起始材料丰富且广泛可获得。设想在本计划中开发的技术将用于天然和非天然治疗剂的合成；这将通过这些方法在马钱子生物碱(-)-脱氢管双酚的全合成中的应用来证明。研究的一部分将研究不对称C-H键激活过程的发展，这是一个化学领域，在很大程度上仍未被探索。