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Characterization of novel core promoter elements

Characterization of novel core promoter elements
新型核心启动子元件的表征
批准号:
7053624
负责人:
Timur Yusufzai
金额:
$4.6万
依托单位国家:
美国
项目类别:
财政年份:
2006
资助国家:
美国
项目状态:
已结题
起止时间:
2006-02-01 至 2008-01-31

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中文摘要
翻译
描述(由申请人提供):本提案侧重于对核心发起人的理解。最近鉴定的核心启动子元件,基序10元件(MTE),位于转录起始位点的下游。一项初步研究发现,MTE的转录需要一种特异性因子(或多种因子),而TATA依赖性转录不需要这种因子。这些因子可能是新的基础转录因子。本研究建议提供了一个大纲,系统研究的MTE及其所需的因素。此外,启动一个项目,涉及的CpG岛作为核心启动子的特性提出。具体而言,(1)纯化和表征介导MTE依赖性转录的因子,这些因子可能是新的基础转录因子;(2)研究TFIID与MTE的相互作用;(3)研究具有核心启动子活性的CpG岛内的序列。总之,这些研究将有助于理解核心启动子和一个基本的细胞过程-转录激活。
英文摘要
DESCRIPTION (provided by applicant): This proposal focuses on the understanding of core promoters. The most recent core promoter element identified, the motif ten element (MTE), is located downstream of the transcription start site. A preliminary study has found that transcription by the MTE requires a specific factor (or factors) that is not required for TATA-dependent transcription. These factors are likely to be novel basal transcription factors. This Research Proposal provides an outline for a systematic study of the MTE and its required factors. In addition, the initiation of a project involving the characterization of CpG islands as core promoters is proposed. Specifically, (1) to purify and characterize the factors that mediate MTE-dependent transcription, ones likely to be novel basal transcription factors; (2) investigate the interaction of TFIID with the MTE; (3) investigate the sequences within the CpG islands that have core promoter activity. Together, these studies will contribute to the understanding of core promoters and a fundamental cellular process- transcription activation.
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Identifying the roles of DNA rewinding enzymes on maintaining genome stability
  • 批准号:
    8861899
  • 项目类别:
  • 资助金额:
    $33.3万
  • 财政年份:
    2015
  • 负责人:
    Timur Yusufzai
  • 依托单位:
Characterization of novel core promoter elements
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