Functional and molecular studies of an interaction between the antigen-presenting molecule MR1 and LILR immune regulatory receptors

抗原呈递分子 MR1 和 LILR 免疫调节受体之间相互作用的功能和分子研究

• 批准号: nhmrc : GNT1165467
• 金额: $ 77.84万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/functional-molecular-studies-regulatory-receptors/1379405
• 关键词: Functional; molecular; studies; interaction; between

Our body’s defense against invading pathogens relies on our immune system. The immune system is made up of multiple cell types that each performs different tasks. In order to function correctly, a family of molecules called inhibitory receptors regulates the immune response. This project will characterize a novel inhibitory receptor axis that we have recently discovered in humans. This may open up new avenues of cancer therapy and autoimmune therapy in the future.

我们人体对入侵病原体的防御依赖于我们的免疫系统。免疫系统由每种执行不同任务的多种单元格类型组成。为了正确功能，称为抑制受体的分子家族调节免疫激素。该项目将表征我们最近在人类中发现的新型抑制受体轴。这可能会在将来开放癌症疗法和自身免疫治疗的新途径。