Functional and molecular studies of an interaction between the antigen-presenting molecule MR1 and LILR immune regulatory receptors

抗原呈递分子 MR1 和 LILR 免疫调节受体之间相互作用的功能和分子研究

• 批准号: nhmrc : GNT1165467
• 金额: $ 77.84万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/functional-molecular-studies-regulatory-receptors/1379405
• 关键词: Functional; molecular; studies; interaction; between

Our body’s defense against invading pathogens relies on our immune system. The immune system is made up of multiple cell types that each performs different tasks. In order to function correctly, a family of molecules called inhibitory receptors regulates the immune response. This project will characterize a novel inhibitory receptor axis that we have recently discovered in humans. This may open up new avenues of cancer therapy and autoimmune therapy in the future.

我们身体对入侵病原体的防御依赖于我们的免疫系统。免疫系统由多种细胞类型组成，每种细胞类型执行不同的任务。为了正常发挥作用，一组被称为抑制性受体的分子调节着免疫反应。这个项目将描述我们最近在人类中发现的一种新的抑制受体轴。这可能为未来的癌症治疗和自身免疫治疗开辟新的途径。