Preliminary Functional Studies of an Understudied NDD Gene in Mice

小鼠中待研究的 NDD 基因的初步功能研究

基本信息

  • 批准号:
    10726239
  • 负责人:
  • 金额:
    $ 14.85万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-07-01 至 2024-06-30
  • 项目状态:
    已结题

项目摘要

Project Summary/Abstract Neurodevelopmental disorders are common, debilitating disorders including autism, intellectual disability, and perhaps even schizophrenia. Recent genetic findings have identified mutations in multiple genes in various cellular pathways as genetic causes of rare neurodevelopmental disorders including autism spectrum disorders, intellectual disability, and others. This proposal will characterize a novel genetic mouse model, already generated by our laboratory and breeding in our laboratory, to delineate the function of a relatively understudied disease gene in the brain. Specifically, the proposal will be on a gene implicated in a well-defined neurodevelopmental disorder. We propose to obtain preliminary behavioral data in this mouse model on multiple ID-related, ASD-related, and control behavioral tasks. In parallel, we will obtain preliminary single nucleus RNA-seq transcriptomics data and perform preliminary analyses while also examining a specific chromatin modification that we predict will be altered in the genetic mutant mouse model. These unbiased, preliminary, experiments will identify novel downstream targets in mammalian brain, elucidate behavioral outcome measures for future studies, and generate new hypotheses anticipated to lead to future potential therapeutic strategies.
项目总结/文摘

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Craig M Powell其他文献

Craig M Powell的其他文献

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{{ truncateString('Craig M Powell', 18)}}的其他基金

Molecular and Cellular Basis of Neurodevelopmental Disorders
神经发育障碍的分子和细胞基础
  • 批准号:
    10347351
  • 财政年份:
    2020
  • 资助金额:
    $ 14.85万
  • 项目类别:
Molecular and Cellular Basis of Neurodevelopmental Disorders
神经发育障碍的分子和细胞基础
  • 批准号:
    10553679
  • 财政年份:
    2020
  • 资助金额:
    $ 14.85万
  • 项目类别:
Striatal synaptic Abnormalities in Models of Autism
自闭症模型中的纹状体突触异常
  • 批准号:
    8235641
  • 财政年份:
    2012
  • 资助金额:
    $ 14.85万
  • 项目类别:
Striatal synaptic Abnormalities in Models of Autism
自闭症模型中的纹状体突触异常
  • 批准号:
    8514726
  • 财政年份:
    2012
  • 资助金额:
    $ 14.85万
  • 项目类别:
Striatal synaptic Abnormalities in Models of Autism
自闭症模型中的纹状体突触异常
  • 批准号:
    8848888
  • 财政年份:
    2012
  • 资助金额:
    $ 14.85万
  • 项目类别:
Striatal synaptic Abnormalities in Models of Autism
自闭症模型中的纹状体突触异常
  • 批准号:
    8662796
  • 财政年份:
    2012
  • 资助金额:
    $ 14.85万
  • 项目类别:
Novel Genetic Models of Autism
自闭症的新遗传模型
  • 批准号:
    8160437
  • 财政年份:
    2011
  • 资助金额:
    $ 14.85万
  • 项目类别:
Novel Genetic Models of Autism
自闭症的新遗传模型
  • 批准号:
    8306800
  • 财政年份:
    2011
  • 资助金额:
    $ 14.85万
  • 项目类别:
Novel Genetic Models of Autism
自闭症的新遗传模型
  • 批准号:
    8725214
  • 财政年份:
    2011
  • 资助金额:
    $ 14.85万
  • 项目类别:
Novel Genetic Models of Autism
自闭症的新遗传模型
  • 批准号:
    8514664
  • 财政年份:
    2011
  • 资助金额:
    $ 14.85万
  • 项目类别:

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