Functional pharmacogenetics: Analysis of the functional effect of the IL28B genotype on hepatitis C virus infection and treatment response.

据估计，全世界有3%的人口感染了丙型肝炎病毒（HCV）。由于自发清除率低，而且对治疗的反应往往很差，许多感染者会出现丙型肝炎病毒的长期并发症。最近的研究已经确定了一种与HCV自发病毒清除和对HCV治疗反应显著相关的遗传变异。我们建议进一步研究该人类基因型对药物反应影响的功能基础。

An estimated 3% of the world�s population is infected with hepatitis C virus (HCV). With low spontaneous clearance rates and often a poor response to treatment many infected individuals will develop long term complications from HCV. Recent studies have identified a genetic variant that is significantly associated with spontaneous viral clearance of HCV and response to treatment for HCV. We propose to further investigate the functional basis for the effect of this human genotype on drug response.