Functional pharmacogenetics: Analysis of the functional effect of the IL28B genotype on hepatitis C virus infection and treatment response.

功能药物遗传学：分析 IL28B 基因型对丙型肝炎病毒感染和治疗反应的功能影响。

• 批准号: nhmrc : 1018079
• 负责人: Dr Kate O'Connor
• 金额: $ 6.26万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Postgraduate Scholarships
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/functional-pharmacogenetics-analysis-treatment-response/109953
• 关键词: Functional; pharmacogenetics; Analysis; functional; effect

An estimated 3% of the world�s population is infected with hepatitis C virus (HCV). With low spontaneous clearance rates and often a poor response to treatment many infected individuals will develop long term complications from HCV. Recent studies have identified a genetic variant that is significantly associated with spontaneous viral clearance of HCV and response to treatment for HCV. We propose to further investigate the functional basis for the effect of this human genotype on drug response.

据估计，世界�S人口中有3%感染丙型肝炎病毒。由于自发转阴率低，而且治疗反应往往很差，许多感染者将发展为丙型肝炎病毒的长期并发症。最近的研究已经确定了一种基因变异，它与丙型肝炎病毒的自发清除和治疗反应显著相关。我们建议进一步研究这种人类基因对药物反应的影响的功能基础。