课题基金 / 基金详情

Mechanisms of Collateral Arteriogenesis in Ishemia

Mechanisms of Collateral Arteriogenesis in Ishemia
缺血中侧支动脉生成的机制
批准号:
7038253
负责人:
DAN CHALOTHORN
金额:
$5.04万
依托单位国家:
美国
项目类别:
财政年份:
2005
资助国家:
美国
项目状态:
已结题
起止时间:
2005-03-18 至 2008-03-17

项目摘要

项目成果

DAN CHALOTHORN的其他基金

相似基金

相关文献

中文摘要
翻译
描述(由申请人提供):本项目的目的是提高我们对缺血性动脉生成的理解。这一过程包括原有小动脉闭塞的向外重塑和新的或“新侧支”的形成,目前还不清楚。此外,许多缺血性疾病患者显示侧支发育缺陷。已经确定了动脉结扎后灌注恢复严重不足的小鼠品系,但损伤的原因尚不清楚。目的我将使用新的方法,我们已经开发的成像动脉生成,将介绍一种新的策略,研究新的侧支形成,并将测试的假设,即新的侧支的形成是有缺陷的应变。有证据表明,形态发生途径,声刺猬缺口,介导的早期血管发育,可能会重新激活在成人损伤和/或重塑。这一途径在动脉形成中的作用尚未研究。我们的初步数据表明Shh信号在侧枝成熟中是重要的。因此,目的II将检查的假设,Shh缺口信号有助于预先存在的侧支成熟和新侧支形成,它是有缺陷的受损菌株。
英文摘要
DESCRIPTION (provided by applicant): The purpose of this project is to improve our understanding of arteriogenesis in ischemia. This process, consisting of outward remodeling of pre-existing arteriole anastomoses and formation of new or "neo-collaterals", is not well understood. Moreover, many patients with ischemic disease show a deficit in collateral development. A mouse strain with a severe deficiency in recovery of perfusion after artery ligation has been identified, but the reasons for the impairment are unknown. Aim I will use new methods we have developed for imaging arteriogenesis, will introduce a new strategy for study of neo-collateral formation, and will test the hypothesis that formation of neo-collaterals is defective in the strain. There is evidence that the morphogenic pathway, Sonic hedgehog-notch, which mediates early vascular development, may be reactivated in adults during injury and/or remodeling. A role for this pathway in arteriogenesis has not been studied. Our preliminary data suggest Shh signaling is important in collateral maturation. Therefore, Aim II will examine the hypothesis that Shh-notch signaling contributes to pre-existing collateral maturation and neo-collateral formation, and that it is defective in the impaired strain.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Genetic Determinants of Collateral Wall Specialization and Ischemic Remodeling
Mechanisms of Collateral Arteriogenesis in Ischemia
Mechanisms of Collateral Arteriogenesis in Ischemia
海外基金