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PHYSICAL BASIS FOR DIAGNOSTIC 19F MR IMAGING

诊断 19F MR 成像的物理基础

基本信息

批准号：
3180419
负责人：
PETER M JOSEPH
金额：
$ 21.8万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
1985
资助国家：
美国
起止时间：
1985-07-01 至 1991-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3180419
关键词：
angiography arterioles blood /plasma substitute blood flow measurement capillary cats cerebrovascular disorder diagnosis computer simulation contrast media fluorine hemodynamics laboratory rat magnetic resonance imaging mathematical model oxygen tension radiotracer

项目摘要

The goal of this project is to develop methods for studying blood perfusion and oxygen tension in the brain using magnetic resonance imaging (MRI) of fluorinated blood substitutes (FBS), and to compare the results with those obtained using several techniques which have been proposed using proton MRI. The major issue is the possibility and desirability of detecting blood flow at the microvessel level, i.e., arterioles, capillaries, and venules. Conventional proton MRI has the major problem that the overwhelming majority of the proton spins come from extravascular water, so that getting adequate suppression of the stationary spins is difficult. Furthermore, most proton MRI flow studies to date have focussed on detecting flow in the major vessels, and methods which may be able to detect microvessel flow are still embryonic. Hence, at present the validity of these proton MRI perfusion techniques is questionable. Fluorine 19 FBS MRI has the unique advantage that the MRI signal comes only from the vascular system, so that the problem of suppressing static spins does not exist. Furthermore, our previous work has shown that FBS MRI can be used to map the mean vascular oxygen tension in vivo. We address the problem of hcw to make FBS MRI sensitive to flow phenomena at the microvessel level, i.e., with velocities less than 1 millimeter per second. We also address the problem of distinguishing the time dependence of the MRI signal due to flow induced washin/washout phenomena from the time dependence of oxygen induced T1 relaxation. We propose to compare quantitative MRI measurements of local blood flow in the cat brain with measurements made using the established technique of radioactive microspheres. We also prcpose qualitative comparison of the microvessel flow velocity field with that demonstrated using autoradiography of 14-C LAP. These results will be compared with several proposed echniques to image caillary flow using proton MRI. As a continuation of our previous work in this field, we intend to evaluate more fluorocarbon compounds in our search for improved biological and physical characteristics needed for FBS MRI.

该项目的目标是开发研究血液的方法脑内的灌注和氧分压氟化血液代用品（FBS）的MRI成像，以及将结果与使用几种技术获得的结果进行比较已经提出使用质子MRI。主要问题是检测血流的可能性和可取性，微血管水平，即，小动脉毛细血管和小静脉常规质子MRI的主要问题是，大多数质子自旋来自血管外的水，很难获得对静止自旋的充分抑制。此外，迄今为止，大多数质子MRI流研究都集中在检测主要血管中的血流，以及能够检测微血管流动的技术还处于萌芽阶段。因此，目前，这些质子MRI灌注技术的有效性是值得怀疑氟19 FBS MRI具有独特的优势， MRI信号仅来自血管系统，因此，不存在抑制静态自旋的问题。此外，委员会认为，我们以前的工作表明，FBS MRI可用于映射体内平均血管氧分压。我们解决这个问题的使FBS MRI对微血管处的流动现象敏感水平，即，其速度小于每秒1毫米。我们还解决了区分时间依赖性的问题由于流动引起的洗入/洗出现象，氧致T1弛豫的时间依赖性。我们提出为了比较局部血流的定量MRI测量结果，猫脑与测量使用已建立的技术放射性微球的。我们还提出了定性微血管流速场与使用14-C同位素的放射自显影术证实。这些结果将与几种提出的技术进行比较，以成像毛细血管流量使用质子核磁共振成像。作为我们以前工作的延续，领域，我们打算评估更多的氟碳化合物在我们的寻求改善所需的生物和物理特性进行FBS MRI。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Effect of interfacial tension on flow of fluorochemicals in the vasculature of the lung: a theoretical and experimental study.

界面张力对肺血管系统中含氟化合物流动的影响：理论和实验研究。

DOI：
10.1007/bf02368451
发表时间：
1990
期刊：
Annals of biomedical engineering
影响因子：
3.8
作者：
Saadi-Elmandjra,M;Joseph,PM;Noordergraaf,A
通讯作者：
Noordergraaf,A

Use of 19F magnetic resonance imaging to measure local cerebral blood volume.

利用19F磁共振成像测量局部脑血容量。

DOI：
10.1002/mrm.1910290205
发表时间：
1993
期刊：
Magnetic resonance in medicine
影响因子：
3.3
作者：
Lu,D;Joseph,PM;Greenberg,JH;Lin,R;Mukherji,B;Sloviter,HA
通讯作者：
Sloviter,HA

Demonstration of differences in vascular permeability in experimental tumors by use of 19F magnetic resonance imaging.

使用 19F 磁共振成像证明实验肿瘤中血管通透性的差异。

DOI：
10.1016/s1076-6332(05)80827-x
发表时间：
1994
期刊：
Academic radiology
影响因子：
4.8
作者：
Meyer,KL;Joseph,PM;Mukherji,B;LiVolsi,VA;Lin,R;Phelan-Belfield,M;Salscheider,M
通讯作者：
Salscheider,M

Effects of intravenous emulsified perfluorochemicals on hepatic cytochrome P-450.

静脉乳化全氟化合物对肝细胞色素 P-450 的影响。