Long-acting depots for treatment of a globally neglected disease

小分子长效注射剂（LAIs）是制药行业感兴趣的一个迅速扩大的领域，正在探索用于传染病（包括全球被忽视的疾病）和癌症等一系列疾病的新机会。此外，给药后药物和制剂的注射后分布，以及这如何影响药物释放仍然知之甚少。因此，该项目的目标是开发用于治疗全球被忽视疾病的药物的长效储存配方和新型成像技术（3D OrbiSIMS和ToF SIMS），以更好地表征注射部位的体内行为。这将提高认识，使未来的合理制定成为可能。

Long acting injections (LAIs) of small molecules are a rapidly expanding area of interest for the pharma industry, with new opportunities being explored for a range of conditions such as infectious disease (including globally neglected diseases), and cancer. Also, the post injection distribution of drug and formulations after administration of LAIs, and how this impacts drug release is still poorly understood. Hence the goals of this project are to develop a long acting depot formulation for a drug used to treat a globally neglected disease and novel imaging techniques (3D OrbiSIMS and ToF SIMS) to better characterise in vivo behaviour at the injection site. This will improve understanding to enable rational formulation development in the future.