Magnetic resonance imaging physics for the study of small vessel disease in humans at ultra-high field

超高场磁共振成像物理研究人类小血管疾病

• 批准号: 2771125
• 金额: --
• 依托单位: University of Glasgow
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2771125
• 关键词: Magnetic; resonance; imaging; physics; study

Studentship strategic priority area: Medical ImagingKeywords: Stroke, MRI, MRA, ASL, parallel-transmitAbstract: The overall aim of the project is to develop 7T MRI methods for vascular and perfusion imaging using multi-transmit RF coils that are being developed by our RF Engineering group for high-resolution imaging the human brain. This will be achieved as a series of sub-projects with the following objectives respectively: (1) the design of optimised pTx pulse sequences using computer simulation; (2) the implementation of these pulse sequences on the 7T MRI scanner using bespoke software development tools; (3) performance testing of the pulse sequences in test objects (phantoms) and healthy subjects; (4) comparison study between multiple RF coils to determine which coil provides the highest quality images for vascular applications; and (5) preliminary clinical study to assess the improvement in characterizing disease in small vessels. All sub-projects will be closely supported by an appropriate post-doctoral member of the research team.

学生奖学金战略优先领域：医学ImagingKeywords：中风，MRI，MRA，ASL，并行传输摘要：该项目的总体目标是开发7 T MRI方法，用于血管和灌注成像，使用多发射RF线圈，由我们的RF工程组开发，用于高分辨率成像人脑。这将通过一系列子项目实现，分别具有以下目标：（1）使用计算机模拟设计优化的pTx脉冲序列;（2）使用定制软件开发工具在7 T MRI扫描仪上实现这些脉冲序列;（3）测试对象中脉冲序列的性能测试（phantomy）和健康受试者之间的比较研究;（4）多个RF线圈之间的比较研究，以确定哪个线圈为血管应用提供最高质量的图像;以及（5）初步临床研究，以评估小血管疾病特征的改善。所有子项目将由研究团队的适当博士后成员密切支持。