A Computational Tool for Simulation of Phonosurgical Pr*

描述(由申请人提供)：该项目的长期目标是通过基于生理的声音模拟来预测喉音外科手术的结果。这项拟议的研究将通过开发一个声带姿势模型来实现这一目标。声带姿势是发声控制的一个基本方面，它被定义为声带的内收、外展或伸长。由于姿势是以喉关节力学和软组织变形为基础的，所以运用连续介质力学的基本理论来建立该模型。将连续介质力学应用于喉部姿势需要对喉部的各种组织进行精确的几何和力学描述，如声带韧带和喉内肌肉。此外，由于这些组织中的许多都是纤维性的，因此具有明显的作用路线，因此需要描绘被动和收缩应力贡献以及纤维方向。当前项目的具体目标是： 在数学上表示分化的喉肌束的方向，允许肌肉力量分布在不同的软骨上。 利用固有肌束的分布，建立声带力学的三维有限元模型，可以预测声带内化和侧化的速度和范围。 模拟I型甲状腺成形术声带外科手术，预测声门结构和修复声带的应力分布。 预计姿势模型将对基于手术的嗓音治疗以及一般的声带建模和手术后治疗产生重大影响。

DESCRIPTION (provided by applicant): The long-term goal of this project is to predict outcomes of laryngeal phonosurgery with physiologically based voice simulation. The proposed research will move towards this goal by developing a model of vocal fold posturing. Vocal fold posturing, a fundamental aspect of phonation control, is defined as adduction, abduction, or elongation of the vocal folds. Because posturing is based on laryngeal joint mechanics and soft tissue deformation, fundamental theories of continuum mechanics are used to formulate this model. The application of continuum mechanics to laryngeal posturing requires an accurate geometric and mechanical description of various tissues in the larynx, such as the vocal ligament and intrinsic laryngeal muscles. Furthermore, because many of these tissues are fibrous and thus have distinct lines of action, a portrayal of passive and contractile stress contributions and fiber direction is needed. The specific aims of the current project are: I. To mathematically represent the orientation of differentiated laryngeal muscle bundles, allowing for distributed muscle forces over various cartilages. II. To create, with the distribution of intrinsic muscle bundles, a three-dimensional finite element model of vocal fold mechanics that can predict both the speed and the range of vocal fold medialization and lateralization. III. To simulate a Type I thyroplasty phonosurgery and predict the resultant glottal configuration as well as the resultant stress distribution in the repaired vocal fold. It is expected that the posturing model will have a significant impact on surgically based voice therapies, as well as on vocal fold modeling in general and post-surgical therapy.