Replicating the cartilage micromechanical environment

复制软骨微机械环境

• 批准号: DP240102160
• 负责人: A/Prof Kathryn Stok
• 金额: $ 40.42万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240102160
• 关键词: Replicating; cartilage; micromechanical; environment

Through a novel, image-guided mechanical evaluation of cell- and tissue-level remodelling, this project aims to unlock new insights into the complex mechanical microenvironment of cartilage and directly influence new strategies in tissue engineering. The research will reveal contributions of cells and extracellular matrix components to mechanical integrity over time. It will build a world-first strain map of the cartilage microenvironment and quantification of dynamic structural remodelling that occurs, providing key targets to improve tissue engineering strategies. The project will also drive innovation in micromechanical testing technology, deliver functional solutions in mechanobiology and advance materials for biological integration.

通过一种新的，图像引导的细胞和组织水平重塑的机械评估，该项目旨在解锁软骨复杂的机械微环境的新见解，并直接影响组织工程的新策略。这项研究将揭示细胞和细胞外基质成分随着时间的推移对机械完整性的贡献。它将建立世界上第一个软骨微环境的应变图和发生的动态结构重塑的量化，为改善组织工程策略提供关键目标。该项目还将推动微机械测试技术的创新，提供机械生物学的功能解决方案，并推进生物集成材料。