Molecular mechanisms of Slit-Robo signalling - investigation of SLIT3:Robo1 interactions during mammalian development

这个项目是世界级的生物科学。它建立在henges和Keavney实验室的研究项目的基础上，以确定心脏发育过程中所需的基因，从而揭示先天性出生缺陷的遗传原因。我们之前在心脏发育方面的工作已经将计算方法应用于人类外显子组和基因组序列分析，这是一种变革性技术，用于识别SLIT3中极有可能影响基因功能并导致人类疾病的变异。通过识别哺乳动物发育过程中所需的基因，我们正在利用好奇心驱动的基础生物科学研究来理解生命的规则。我们对心脏发育和SLIT-ROBO信号之间联系的研究，推进了我们对发育过程中正常生理的理解，并正在应对利用生物科学提供对健康的综合理解的战略挑战。

This project is world-class bioscience. It builds upon research programmes in the Hentges and Keavney laboratories to identify genes required during development of the heart, and thereby reveal the genetic causes of congenital birth defects. Our prior work on cardiac development has applied computational methods for human exome and genome sequence analysis, which are transformative technologies, to identify variants in SLIT3 that are highly likely to affect gene function and cause human disease. By identifying genes required during mammalian development, we are using curiosity-driven fundamental bioscience research to understand the rules of life. Our investigation into links between heart development and SLIT-ROBO signalling, advances our understanding of normal physiology during development, and is tackling the strategic challenge of using biosciences to provide an integrated understanding of health.