Mapping organic and inorganic chemistry with ageing in bone tissue

绘制有机和无机化学与骨组织老化的关系

• 批准号: 2775845
• 金额: --
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2775845
• 关键词: Mapping; organic; inorganic; chemistry; ageing

The project provides high-level training in current biomolecular and elemental mapping techniques and the student will develop a range of transferable professional skills that will equip them for a career either in academic research or in the bioeconomy industries. The proposed research takes an inter-disciplinary approach by combining cutting-edge proteomics methods (Buckley) together with other imaging techniques that further study the protein component (immunohistochemistry; Hoyland) and elemental mapping of the inorganic component via synchrotron XRF (Manning), with the outcome of an improved understanding of bone ageing across a range of vertebrates, particularly contrasting mammalian bone growth with the distinct processes of fish.

该项目提供当前生物分子和元素映射技术的高水平培训，学生将开发一系列可转移的专业技能，使他们能够在学术研究或生物经济行业中从事职业生涯。拟议的研究采取了跨学科的方法，将尖端的蛋白质组学方法（巴克利）与其他成像技术相结合，进一步研究蛋白质组分（免疫组织化学; Hoyland）和通过同步加速器XRF（Manning）对无机成分进行元素测绘，从而提高了对一系列脊椎动物骨老化的理解，特别是将哺乳动物的骨骼生长与鱼类的不同过程进行对比。