Mapping organic and inorganic chemistry with ageing in bone tissue

该项目提供当前生物分子和元素图谱技术的高水平培训，学生将培养一系列可转移的专业技能，为他们在学术研究或生物经济行业的职业生涯做好准备。拟议的研究采用跨学科方法，将尖端蛋白质组学方法（Buckley）与其他成像技术相结合，进一步研究蛋白质成分（免疫组织化学；Hoyland）和通过同步加速器 XRF（Manning）对无机成分进行元素图谱，从而更好地了解一系列脊椎动物的骨骼老化，特别是对比哺乳动物骨骼生长与鱼类的独特过程。

The project provides high-level training in current biomolecular and elemental mapping techniques and the student will develop a range of transferable professional skills that will equip them for a career either in academic research or in the bioeconomy industries. The proposed research takes an inter-disciplinary approach by combining cutting-edge proteomics methods (Buckley) together with other imaging techniques that further study the protein component (immunohistochemistry; Hoyland) and elemental mapping of the inorganic component via synchrotron XRF (Manning), with the outcome of an improved understanding of bone ageing across a range of vertebrates, particularly contrasting mammalian bone growth with the distinct processes of fish.