Inorganic/Organic Nanocomposite Particles (I/O-NP); A Platform Technology for Next Generation Healthcare Applications

无机/有机纳米复合粒子（I/O-NP）；

• 批准号: MR/Y020170/1
• 负责人: Marco Giardiello
• 金额: $ 75.89万
• 依托单位: University of Liverpool
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FY020170%2F1
• 关键词: Inorganic; Organic; Nanocomposite; Particles; NP

Inorganic/Organic Nanocomposite Particles (I/O-NP) are a highly versatile platform technology, currently being developed for use in diagnostic medical applications. I/O-NPs are composed of functional polymeric organic nanoscale structures (50-200 nm) in which smaller metallic nanoparticles (2-20 nm) are encapsulated. The synthetic versatility of the platform technology allows for fine tuning of the composition and architectures of the nanoscale structures, thus offering the potential for a new class of biologically responsive, functional materials to be developed.The incorporation of magnetic iron oxide nanoparticles within biologically responsive organic nanostructures would give rise to composite materials that could (a) swell or contract in response to biological stimuli or (b) accumulate around a biological target. In either case, the magnetic characteristics of the iron oxides employed would be varied as a result of changes in their rotation dynamics and interparticle proximity. Such magnetic property variation could be exploited to design detection systems, capable of detecting minute quantities of biological stimulus.As biological tissue contains no magnetic material, the versatility of the I/O-NP platform technology offers a range of potential for wide healthcare applications, providing more sensitive, specific, and quantitative diagnostic analysis, with real-time monitoring and quantification in biological systems potential with no background signal.The specific aims of this FLF renewal are towards the creation of world-leading expertise, building towards the future establishment of the Advanced Magnetic Materials for Healthcare Hub (AM4H) at UoL. The Hub will allow for a cross-disciplinary community of researchers in fields of Materials Science, Biology, Physics and Clinical Sciences to build synergies and research projects around cutting-edge technologies that are currently not present in the UK or Europe.The fellowship applicant, Dr Marco Giardiello, has built a global reputation through his cross-disciplinary collaborations and experience of inorganic and organic nanomedicine research in both diagnostic and therapeutic areas. The research programme is to be carried out at the University of Liverpool's Department of Chemistry, with critical cross-faculty, cross-sector and multi-disciplinary collaboration in place to ensure its successful outcomes as well as long-term future I/O-NP wide platform technology development.The fellowship renewal's key aims are:1. Novel smart and biologically responsive Inorganic/Organic Nanocomposite Particle development2. Novel device engineering and pre-clinical investigation, ensuring IP generation and industrial engagement3. Establishment of multidisciplinary research strategies, fostering networks to set the foundation towards the creation of the Advanced Magnetic Materials for Healthcare Hub (AM4H)4. Wide I/O-NP platform technology expansion towards multiple global healthcare needs

无机/有机纳米复合材料颗粒（I/O-NP）是一种通用的平台技术，目前正在用于诊断医学应用中。 I/O-NP由功能性聚合有机纳米级结构（50-200 nm）组成，其中较小的金属纳米颗粒（2-20 nm）封装。平台技术的合成多功能性允许对纳米级结构的组成和体系结构进行微调，从而为生物学响应的有机纳米结构内的磁性氧化铁纳米颗粒的融合提供了生物响应的有机纳米结构的可能会引起生物学反应材料，从而使生物学反应型的氧化铁纳米粒子在生物学上的组合中会产生一定的刺激或合成的刺激（BAIRGISE）（BAIRGIANITY）的潜力（BAIRGIANITY）会激发（BBORGIATIE）（BAIRGIATIES）启动（BB响应（BB），氧化型氧化铁纳米颗粒的纳入构建可能会产生（a）刺激（a）。无论哪种情况，由于其旋转动力学和颗粒间接近度的变化，所采用的铁氧化物的磁特性都将变化。这种磁性特性变化可以利用到设计检测系统，能够检测微量的生物刺激。因为生物组织不包含磁性材料，I/O-NP平台技术的多功能性为广泛的医疗保健提供了一系列潜在的潜力，可提供更敏感的，特定的，特定于实时的诊断和量化的量子，以实时监测和定量的量化。创建世界领先的专业知识，建立在UOL的未来建立医疗保健中心（AM4H）的磁性材料。该枢纽将允许材料科学，生物学，物理学和临床科学领域的研究人员组成一个跨学科的社区，以建立围绕英国或欧洲目前不存在的尖端技术的协同效应和研究项目。治疗区域。该研究计划将在利物浦大学的化学系进行，并进行关键的跨教师，跨部门和多学科合作，以确保其成功的成果以及长期未来的I/O-NP宽平台技术开发。新颖的智能和生物学响应的无机/有机纳米复合粒子颗粒的发育2。新颖的设备工程和临床前研究，确保IP产生和工业参与3。建立多学科研究策略，促进网络为创建医疗保健中心（AM4H）4的高级磁性材料的基础4。广泛的I/O-NP平台技术扩展到多个全球医疗保健需求