GAR TFASE AND ATIC: STRUCTURE, MECHANISM AND INHIBITION
GAR TFASE AND ATIC: STRUCTURE, MECHANISM AND INHIBITION
批准号:
6841636
负责人:
IAN A WILSON
金额:
$125.55万
依托单位国家:
美国
项目类别:
财政年份:
1994
资助国家:
美国
项目状态:
已结题
起止时间:
1994-07-01 至 2006-12-31
期刊论文(31)
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科研奖励(0)
会议论文
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Towards structure-based drug design: crystal structure of a multisubstrate adduct complex of glycinamide ribonucleotide transformylase at 1.96 A resolution.
迈向基于结构的药物设计:甘氨酰胺核糖核苷酸转化酰酶多底物加合物复合物的晶体结构,分辨率为 1.96 A。
DOI:
10.1006/jmbi.1995.0286
发表时间:
1995
期刊:
Journal of molecular biology.
影响因子:
--
作者:
[Klein,C, Chen,P, Arevalo,JH, Stura,EA, Marolewski,A, Warren,MS, Benkovic,SJ, Wilson,IA]
通讯作者:
Wilson,IA
10-(2-benzoxazolcarbonyl)-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid: a potential inhibitor of GAR transformylase and AICAR transformylase.
10-(2-苯并恶唑羰基)-5,10-二脱氮杂-无环-5,6,7,8-四氢叶酸:GAR 转化酶和 AICAR 转化酶的潜在抑制剂。
DOI:
10.1016/s0968-0896(03)00457-7
发表时间:
2003
期刊:
Bioorganic & medicinal chemistry
影响因子:
3.5
作者:
[Marsilje,ThomasH, Hedrick,MichaelP, Desharnais,Joel, Capps,Kevin, Tavassoli,Ali, Zhang,Yan, Wilson,IanA, Benkovic,StephenJ, Boger,DaleL]
通讯作者:
Boger,DaleL
Crystal structure of avian aminoimidazole-4-carboxamide ribonucleotide transformylase in complex with a novel non-folate inhibitor identified by virtual ligand screening.
通过虚拟配体筛选鉴定出禽类氨基咪唑-4-甲酰胺核糖核苷酸转化酶与新型非叶酸抑制剂复合物的晶体结构。
DOI:
10.1074/jbc.m406801200
发表时间:
2004
期刊:
The Journal of biological chemistry
影响因子:
--
作者:
[Xu,Lan, Li,Chenglong, Olson,ArthurJ, Wilson,IanA]
通讯作者:
Wilson,IanA
A pH-dependent stabilization of an active site loop observed from low and high pH crystal structures of mutant monomeric glycinamide ribonucleotide transformylase at 1.8 to 1.9 A.
在 1.8 至 1.9 A 下,从突变型单体甘氨酰胺核糖核苷酸转化酶的低 pH 和高 pH 晶体结构中观察到活性位点环的 pH 依赖性稳定。
DOI:
10.1006/jmbi.1998.1931
发表时间:
1998
期刊:
Journal of molecular biology.
影响因子:
--
作者:
[Su,Y, Yamashita,MM, Greasley,SE, Mullen,CA, Shim,JH, Jennings,PA, Benkovic,SJ, Wilson,IA]
通讯作者:
Wilson,IA
DOI:
10.1021/bi4005182
发表时间:
2013-07-30
期刊:
BIOCHEMISTRY
影响因子:
2.9
作者:
[Connelly, Stephen, DeMartino, Jessica K., Boger, Dale L., Wilson, Ian A.]
通讯作者:
Wilson, Ian A.
共 12 条
Structural Biology Core
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批准号:10549644
-
项目类别:
-
资助金额:$36.2万
-
财政年份:2023
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负责人:IAN A WILSON
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依托单位:
Structural and Modeling Core
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批准号:10514323
-
项目类别:
-
资助金额:$565.96万
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财政年份:2022
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负责人:IAN A WILSON
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依托单位:
High-throughput assays and small-molecule discovery of antiviral candidates targeting influenza hemagglutinin
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批准号:10397532
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项目类别:
-
资助金额:$67.85万
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财政年份:2021
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负责人:IAN A WILSON
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依托单位:
High-throughput assays and small-molecule discovery of antiviral candidates targeting influenza hemagglutinin
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批准号:10612773
-
项目类别:
-
资助金额:$67.85万
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财政年份:2021
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负责人:IAN A WILSON
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依托单位:
Exploiting Vulnerability on Influenza Virus
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批准号:9526599
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项目类别:
-
资助金额:$73.02万
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财政年份:2017
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负责人:IAN A WILSON
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依托单位:
PROJECT 2:Structural studies of SOSIP trimers
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批准号:10336287
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项目类别:
-
资助金额:$20.95万
-
财政年份:2015
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负责人:IAN A WILSON
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依托单位:
PROJECT 2:Structural studies of SOSIP trimers
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批准号:10643721
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项目类别:
-
资助金额:$108.42万
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财政年份:2015
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负责人:IAN A WILSON
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依托单位:
Exploiting sites of vulnerability on influenza viruses
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批准号:9114253
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项目类别:
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资助金额:$83.59万
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财政年份:2015
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负责人:IAN A WILSON
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依托单位:
PROJECT 2:Structural studies of SOSIP trimers
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批准号:10427133
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项目类别:
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资助金额:$119.94万
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财政年份:2015
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负责人:IAN A WILSON
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依托单位:
PROJECT 2:Structural studies of SOSIP trimers
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批准号:10083182
-
项目类别:
-
资助金额:$121.73万
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财政年份:2015
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负责人:IAN A WILSON
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依托单位:
Structural insights into pandemic and emerging influenza viruses
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批准号:8644586
-
项目类别:
-
资助金额:$82.26万
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财政年份:2013
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负责人:IAN A WILSON
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依托单位:
IAN WILSON PRT TIME
-
批准号:8362033
-
项目类别:
-
资助金额:$0.74万
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财政年份:2011
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负责人:IAN A WILSON
-
依托单位:
X-RAY CRYSTALLOGRAPHY OF IMMUNE-RELATED MOLECULES
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批准号:8362147
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项目类别:
-
资助金额:$1.08万
-
财政年份:2011
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负责人:IAN A WILSON
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依托单位:
NOVEL ANTI-CANCER DRUG DESIGN TARGETING AICAR TRANSFORMYLASE
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批准号:8169342
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项目类别:
-
资助金额:$1.12万
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财政年份:2010
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负责人:IAN A WILSON
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依托单位:
Joint Center for Structural Genomics
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批准号:8337512
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项目类别:
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资助金额:$8.95万
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财政年份:2010
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负责人:IAN A WILSON
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依托单位:
Joint Center for Structural Genomics
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批准号:8287734
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项目类别:
-
资助金额:$68.22万
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财政年份:2010
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负责人:IAN A WILSON
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依托单位:
Joint Center for Structural Genomics
-
批准号:8511710
-
项目类别:
-
资助金额:$792.01万
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财政年份:2010
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负责人:IAN A WILSON
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依托单位:
Admin Core
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批准号:8151681
-
项目类别:
-
资助金额:$87.62万
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财政年份:2010
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负责人:IAN A WILSON
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依托单位:
TOWARD DEVELOPING NEW ANTIVIRALS AGAINST AVIAN INFLUENZA MEMBRANE GLYCOPROTEINS
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批准号:8169360
-
项目类别:
-
资助金额:$1.12万
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财政年份:2010
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负责人:IAN A WILSON
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依托单位:
Joint Center for Structural Genomics
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批准号:8132307
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项目类别:
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资助金额:$742.72万
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财政年份:2010
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负责人:IAN A WILSON
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依托单位:
海外基金