Functional validation of FoxP3 target genes in human regulatory T cells
Functional validation of FoxP3 target genes in human regulatory T cells
批准号:
nhmrc : 565314
负责人:
Prof Frances Shannon
金额:
$36.36万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2009
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2009-01-01 至 2011-12-31
中文摘要
使用基于DNA的技术,我们专注于被称为调节性T细胞的罕见白色血细胞。这些细胞是免疫系统的警察,负责维持平衡的免疫反应,并防止对无害物质的攻击。这些细胞可以预防健康个体的自身免疫性疾病,只有首先了解它们是如何正常工作的,我们才能研究和纠正自身免疫性疾病(如1型糖尿病)的缺陷。
英文摘要
Using DNA based technologies we have focused on rare white blood cells known as regulatory T cells. These cells are policeman of the immune system and are responsible for maintaining balanced immune reactions, and preventing attack against harmless substances. These cells prevent autoimmune disease in healthy individuals, and only by first understanding how they work normally can we investigate and correct the defects in autoimmune diseases such as type 1 diabetes.
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会议论文
Regulation of expression of microRNAs involved in EMT
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批准号:nhmrc : 1008440
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项目类别:NHMRC Project Grants
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资助金额:$37.3万
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财政年份:2011
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负责人:Prof Frances Shannon
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依托单位:
The transcription factors c-Rel and RelA serve distinct roles in the devlopment and function of CD4 Regulatory T cells
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批准号:nhmrc : 543141
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项目类别:NHMRC Project Grants
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资助金额:$32.87万
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财政年份:2009
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负责人:Prof Frances Shannon
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依托单位:
The role of c-Rel in controlling chromatin architecture and transcription networks in T lymphocytes
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批准号:nhmrc : 418048
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资助金额:$35.45万
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财政年份:2007
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依托单位:
The role of NF-kB transcription factors in regulating T cell transcription networks
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批准号:nhmrc : 316917
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项目类别:NHMRC Project Grants
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资助金额:$35.61万
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财政年份:2005
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负责人:Prof Frances Shannon
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依托单位:
Gene transcription in activated T cells: a model of chromatin remodeling.
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批准号:nhmrc : 224209
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项目类别:NHMRC Project Grants
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资助金额:$31.84万
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财政年份:2003
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负责人:Prof Frances Shannon
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依托单位:
The role of c-Rel in preventing HIV induced apoptosis
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批准号:nhmrc : 981893
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项目类别:NHMRC Strategic Awards
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资助金额:$17.82万
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财政年份:1998
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负责人:Prof Frances Shannon
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依托单位:
Transcriptional activation of cytokine genes by the HIV transactivator tat
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批准号:nhmrc : 970216
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项目类别:NHMRC Strategic Awards
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资助金额:$19.97万
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财政年份:1997
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负责人:Prof Frances Shannon
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依托单位:
海外基金