Regulation of expression of microRNAs involved in EMT

大多数癌症死亡是由于转移，即癌细胞变得侵袭性和迁移性。我们的目标是了解控制这一过程的分子机制，这可能会导致识别对诊断和治疗癌症转移有潜在帮助的分子。我们将研究TGF -如何调节ZEB蛋白的表达，ZEB蛋白如何抑制关键的microrna，以及ZEB靶向哪些其他基因。

The majority of deaths from cancer are due to metastasis, which involves cancer cells becoming invasive and migratory. We aim to understand the molecular mechanisms that control this process, which may lead to identification of molecules that are potentially useful for diagnosing and treating cancer metastasis. We will investigate how TGF� regulates the expression of ZEB proteins, how the ZEB proteins function to repress key microRNAs, and what other genes are targeted by the ZEBs.