Understanding how macrophages respond to damage-derived inflammatory signals.

这个项目将促进一种创造性和好奇心驱动的方法，以解决生物学中的一个基本问题，即翻译后修饰如何控制对炎症危险信号的反应，以维持体内平衡？由于P2X7R在巨噬细胞以外的细胞中表达，即内皮细胞和上皮细胞、T细胞或先天淋巴样细胞，了解控制P2X7R信号转导的机制将利用跨多个学科的知识、工具和专业知识，如信号转导、受体运输和免疫与炎症，符合BBSRC的“理解生命规则”的职责。此外，该项目还符合“生物科学对健康的综合理解”，因为该项目将对在压力和生物或环境挑战下保持健康和健康所需的细胞机制有新的理解。该项目将提供专业知识深度的多学科培训，并使博士生掌握广泛的专业技能和可转让的技能。

This project will promote a creative and curiosity-driven approach to address a fundamental question in biology How posttranslational modifications control responses to the inflammatory danger signals to maintain homeostasis? As P2X7Rs are expressed in cells other than macrophages i.e. endothelial and epithelial cells, T cells or Innate Lymphoid cells understanding the mechanism that control P2X7R signalling will leverage knowledge, tools and expertise across multiple disciplines such as Signal transduction, Receptor trafficking and Immunity and Inflammation fitting with the "Understanding the rules of life" remit of BBSRC. In addition, this project also fits the "Bioscience for an integrated understanding of health" as this project will bring a new understanding on cellular mechanisms required to maintain health and wellness under stress and biological or environmental challenges. This project will provide a multidisciplinary training for depth of expertise as well as equipping the PhD student with a breadth of professional and transferable skills.