Bring out your dead - how does defective apoptotic cell clearance by tingible body macrophages lead to the activation of self-reactive B cells in SLE?

点击翻译按钮获取中文摘要

Good housekeeping is critical to the day-to-day running of the immune system. In the case of the germinal centre, a key structure where plasma cells are generated, the ability to clear away dead and dying cells is critical because failure to do so can lead to the spillover of cellular waste and debris into the follicle where they can activate harmful B cells to make autoantibodies and cause disease. Understanding how this happens can lead to new ways to target and treat autoimmune diseases.