Functions of Arnt1 and Arnt2

Arnt1 和 Arnt2 的功能

• 批准号: nhmrc : GNT1070909
• 负责人: A/Pr Daniel Peet
• 金额: $ 33.95万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/functions-arnt1-arnt2/1344999
• 关键词: Functions; Arnt1; Arnt2

Understanding the precise control of neuronal genes related to appetite and obesity, and neuropsychiatric disorders and dementia, is complicated by some gene regulating proteins having highly related sequences. This project will eludcidate how two closely related proteins can determine specific target gene outputs, information important for designing methods to control activities of neurological disease related genes within cells.

理解与食欲和肥胖、神经精神障碍和痴呆相关的神经元基因的精确控制，由于一些具有高度相关序列的基因调节蛋白而变得复杂。该项目将阐明两种密切相关的蛋白质如何决定特定的靶基因输出，这些信息对于设计控制细胞内神经疾病相关基因活动的方法非常重要。