Is Hypoxia Inducible Factor 2 the Trigger of the Angiogenic Switch and a Driver of Disease Progression in Myeloma?
Is Hypoxia Inducible Factor 2 the Trigger of the Angiogenic Switch and a Driver of Disease Progression in Myeloma?
批准号:
nhmrc : 626911
负责人:
A/Pr Daniel Peet
金额:
$40.35万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2010
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2010-01-01 至 2012-12-31
中文摘要
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英文摘要
Multiple myeloma (MM) is a fatal cancer of plasma cells (PC). PC migrate to the bone marrow, which compared with other organs is low in oxygen (hypoxic). In response to this hypoxia, the cancer cells turn on the expression of genes called hypoxia-inducible factors (HIF). HIFs activate the expression of genes that encourage blood vessel formation, which in turn stimulates greater tumour growth and disease progression. This proposal will investigate the role of HIFs in the progression of MM.
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Functions of Arnt1 and Arnt2
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依托单位:
海外基金