The impact of peri-operative analgesia on neuropharmacological outcomes in rodent models of chronic pain.

围手术期镇痛对慢性疼痛啮齿动物模型神经药理学结果的影响。

• 批准号: 2779106
• 金额: --
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2779106
• 关键词: impact; peri; operative; analgesia; neuropharmacological

Chronic pain affects approximately 20% of the population, and since currently prescribed analgesics are ineffective in three quarters of these individuals, identifying novel pharmacotherapeutic targets is imperative. Multiple mechanisms contribute to the pain of a single disease and animal research is vital in order that we may expand our knowledge regarding the underlying causes of persistent pain states. It is possible to model varied chronic pain diseases in rodent models. This involves the use of surgical procedures that ethically require analgesia. However, since basic pain researchers wish to measure pain-related behaviours animals are more often that not denied peri-operative analgesia. This in turn means that pain will arise not only from the disease-inducing surgery, but also from the tissue damage/inflammation associated with the surgical incisions themselves. In the first part of my PhD I want to refine peri-operative analgesic administration for rodents undergoing surgeries, potentially reducing their unnecessary post-operative pain. The second part of my PhD focus on the functionality of descending modulatory pathways in certain disease states while monitoring any detrimental effect of peri-operative analgesia on neuropharmacological outcomes.

慢性疼痛影响约20%的人群，由于目前处方的镇痛药对这些人中的四分之三无效，因此必须确定新的药理学靶点。多种机制会导致单一疾病的疼痛，动物研究至关重要，以便我们扩大有关持续性疼痛状态根本原因的知识。可以在啮齿动物模型中模拟各种慢性疼痛疾病。这涉及到在伦理上需要镇痛的外科手术的使用。然而，由于基础疼痛研究人员希望测量疼痛相关的行为，动物更经常不拒绝围手术期镇痛。这反过来意味着疼痛不仅来自诱发疾病的手术，而且来自与手术切口本身相关的组织损伤/炎症。在我的博士学位的第一部分，我想改进手术期间啮齿动物的镇痛药给药，可能会减少他们不必要的术后疼痛。我博士学位的第二部分专注于某些疾病状态下下行调节通路的功能，同时监测围手术期镇痛对神经药理学结果的任何不利影响。