The impact of peri-operative analgesia on neuropharmacological outcomes in rodent models of chronic pain.

慢性疼痛影响了大约20%的人口，由于目前处方止痛药对其中四分之三的人无效，因此确定新的药物治疗靶点势在必行。多种机制导致单一疾病的疼痛，动物研究是至关重要的，以便我们可以扩大我们关于持续疼痛状态的潜在原因的知识。在啮齿类动物模型中模拟各种慢性疼痛疾病是可能的。这涉及到伦理上需要止痛的外科手术的使用。然而，由于基础疼痛研究人员希望测量与疼痛相关的行为，动物往往不被拒绝围手术期镇痛。这反过来意味着疼痛不仅来自于引起疾病的手术，还来自于与手术切口本身相关的组织损伤/炎症。在我博士学位的第一部分，我想改进手术中啮齿动物的围手术期镇痛管理，潜在地减少它们不必要的术后疼痛。我博士的第二部分专注于某些疾病状态下下行调节通路的功能，同时监测围手术期镇痛对神经药理学结果的任何有害影响。

Chronic pain affects approximately 20% of the population, and since currently prescribed analgesics are ineffective in three quarters of these individuals, identifying novel pharmacotherapeutic targets is imperative. Multiple mechanisms contribute to the pain of a single disease and animal research is vital in order that we may expand our knowledge regarding the underlying causes of persistent pain states. It is possible to model varied chronic pain diseases in rodent models. This involves the use of surgical procedures that ethically require analgesia. However, since basic pain researchers wish to measure pain-related behaviours animals are more often that not denied peri-operative analgesia. This in turn means that pain will arise not only from the disease-inducing surgery, but also from the tissue damage/inflammation associated with the surgical incisions themselves. In the first part of my PhD I want to refine peri-operative analgesic administration for rodents undergoing surgeries, potentially reducing their unnecessary post-operative pain. The second part of my PhD focus on the functionality of descending modulatory pathways in certain disease states while monitoring any detrimental effect of peri-operative analgesia on neuropharmacological outcomes.