Translational Multimodal Strategy for Peri-Implant Disease Prevention

牙种植体已经成为牙科实践中的一个重要常规组成部分，有500多万个固定装置 每年在美国投放，这一数字预计未来将大幅增加。这个 种植体周软组织界面在抵抗细菌侵袭、增强 对随后的种植体周围疾病的易感性。种植体周围疾病是影响 牙科植入物周围的软/硬组织。大量的实验证据表明， 牙菌斑在软组织-种植体界面的堆积和随后的局部炎症 反应似乎是种植体周围粘膜炎发病机制中的关键。此外，在某些人身上，它 会发展为种植体周围炎，导致牙槽骨丢失和种植失败。此应用程序的目标是 为了创建一种新的牙种植体构造，其在提供种植体支持的修复体抗生物膜的同时 提供了一种紧密的牙龈组织植入密封，作为细菌入侵的屏障。这款智能牙科产品 植入系统是从人体口腔运动转换生物机械力的无电池系统(例如， 咀嚼或刷牙)转化为电能，并为发光二极管供电，使就地 光疗法。当与持久的抗菌膜修复表面结合使用时，这款自给式 精密光疗系统避免了使用常规抗菌剂带来的问题。正在进行中 研究表明，红光和近红外光可以有效地维持人牙龈组织细胞的活性 面对单一和多个微生物的挑战。此外，抗菌膜修复表面几乎 完全抑制细菌定植。基于这些令人兴奋的支持数据，我们假设力- 结合细菌防粘剂的压电晶体产生红光和近红外光的动力 修复体创造了一个抗炎、促进愈合的环境，提供了坚固的软组织密封和 防止种植体周围炎的发展。我们预计这种下一代反- 炎性、抗生物膜牙科种植系统将增加功能并提供一种新的策略 预防和控制种植体周围疾病，特别是在高危人群中，降低种植体的风险 失败了。

Dental implants have become an important routine component of dental practice with over five million fixtures placed annually in the United States and this number is expected to increase significantly in the future. The peri-implant soft tissue interface is less effective than natural teeth in resisting bacterial invasion, enhancing vulnerability to subsequent peri-implant disease. Peri-implant diseases are inflammatory conditions affecting the soft/hard tissues surrounding a functional dental implant. Plenty of experimental evidence indicates that the accumulation of dental plaque at the soft tissue-implant interface and the subsequent local inflammatory response seems to be key in the pathogenesis of peri-implant mucositis. Furthermore, in certain individuals, it will progress to peri-implantitis, resulting in alveolar bone loss and implant failure. The goal of this application is to create a novel dental implant construct that renders the implant-supported restoration antibiofilm while providing a tight gingival tissue-implant seal that serves as a barrier to bacterial invasion. This smart dental implant system is a battery-less system that converts biomechanical forces from human oral motions (e.g., chewing or tooth-brushing) into electrical energy and powers light-emitting diodes that enable in situ phototherapy. When used in combination with a long-lasting antibiofilm restorative surface, this self-powered precision phototherapy system circumvents problems with the use of conventional antimicrobials. Ongoing studies indicate that red and near-infrared light is effective in maintaining human gingival tissue cell viability in the face of mono- and multi-microbial challenges. Furthermore, the antibiofilm restorative surface almost completely inhibits bacterial colonization. Based on these exciting supporting data, we hypothesize that force- powering of piezoelectric crystals to produce red and near-infrared light combined with bacterial anti-adhesive restorations creates an anti-inflammatory, pro-healing environment that provides a robust soft-tissue seal and prevents the development of peri-implantitis. We anticipate that the creation of this next-generation anti- inflammatory, antibiofilm dental implant system would increase functionality and provide a new strategy to prevent and control peri-implant diseases, especially in populations at risk, and reduce the risk of implant failure.