Translational Multimodal Strategy for Peri-Implant Disease Prevention
种植体周围疾病预防的转化多模式策略
基本信息
- 批准号:10736860
- 负责人:
- 金额:$ 52.13万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-08-01 至 2028-04-30
- 项目状态:未结题
- 来源:
- 关键词:3-DimensionalAddressAdhesionsAdhesivesAffectAgeAlveolar Bone LossAnti-Bacterial AgentsAnti-Inflammatory AgentsApoptosisBacterial AdhesionBicuspidBiomechanicsBite ForceBone ResorptionCell CommunicationCell ProliferationCell SurvivalCell physiologyCellsClinicalCoculture TechniquesCrownsDataDental General PracticeDental ImplantsDental PlaqueDental crownsDevelopmentDiseaseDoseEngineeringEnvironmentEpithelial CellsFailureFibroblastsFutureGenerationsGingivaGoalsHeadHumanImplantIn SituIndividualInflammationInflammation MediatorsInflammatoryInflammatory ResponseInvadedJoint ProsthesisLigatureLightLimb ProsthesisLongevityMasticationMeasuresMechanicsMediatingMicrobeMicrobial BiofilmsModelingMolar toothMotionMucositisOperative Surgical ProceduresOralOsseointegrationOutcomePathogenesisPatientsPeriodontitisPhenotypePhototherapyPopulations at RiskProductionPropertyProtocols documentationRecording of previous eventsResistanceRisk ReductionRuptureSamplingSecureSelf AssessmentSignal PathwaySilkSmokingStimulusStructureSurfaceSystemSystemic diseaseTestingTissuesTitaniumTooth structureToothbrushingUnited StatesX-Ray Computed Tomographyalveolar boneantimicrobialantimicrobial peptideclinical examinationclinical practicecytokinedisorder preventiondosageefficacy evaluationefficacy testingelectrical potentialexperimental studyhealinghuman tissueimplantable devicein vivo Modelin vivo evaluationinnovationkeratinocytelight emissionmicroCTmicrobialmultimodalitynext generationnoveloral pathogenparticlepathogenic microbeperi-implantitisphotobiomodulationporcine modelpreservationpreventresponserestorationsealself assemblysenescencesoft tissuetissue culture
项目摘要
Dental implants have become an important routine component of dental practice with over five million fixtures
placed annually in the United States and this number is expected to increase significantly in the future. The
peri-implant soft tissue interface is less effective than natural teeth in resisting bacterial invasion, enhancing
vulnerability to subsequent peri-implant disease. Peri-implant diseases are inflammatory conditions affecting
the soft/hard tissues surrounding a functional dental implant. Plenty of experimental evidence indicates that the
accumulation of dental plaque at the soft tissue-implant interface and the subsequent local inflammatory
response seems to be key in the pathogenesis of peri-implant mucositis. Furthermore, in certain individuals, it
will progress to peri-implantitis, resulting in alveolar bone loss and implant failure. The goal of this application is
to create a novel dental implant construct that renders the implant-supported restoration antibiofilm while
providing a tight gingival tissue-implant seal that serves as a barrier to bacterial invasion. This smart dental
implant system is a battery-less system that converts biomechanical forces from human oral motions (e.g.,
chewing or tooth-brushing) into electrical energy and powers light-emitting diodes that enable in situ
phototherapy. When used in combination with a long-lasting antibiofilm restorative surface, this self-powered
precision phototherapy system circumvents problems with the use of conventional antimicrobials. Ongoing
studies indicate that red and near-infrared light is effective in maintaining human gingival tissue cell viability in
the face of mono- and multi-microbial challenges. Furthermore, the antibiofilm restorative surface almost
completely inhibits bacterial colonization. Based on these exciting supporting data, we hypothesize that force-
powering of piezoelectric crystals to produce red and near-infrared light combined with bacterial anti-adhesive
restorations creates an anti-inflammatory, pro-healing environment that provides a robust soft-tissue seal and
prevents the development of peri-implantitis. We anticipate that the creation of this next-generation anti-
inflammatory, antibiofilm dental implant system would increase functionality and provide a new strategy to
prevent and control peri-implant diseases, especially in populations at risk, and reduce the risk of implant
failure.
牙科植入物已成为牙科实践的重要常规组成部分,超过500万个固定装置
每年在美国进行,预计这一数字将在未来大幅增加。的
种植体周围软组织界面在抵抗细菌侵袭、增强
易受随后的植入物周围疾病的影响。种植体周围疾病是影响
功能性牙科植入物周围的软/硬组织。大量的实验证据表明,
牙菌斑在软组织-种植体界面处的积聚以及随后的局部炎症
反应似乎是种植体周围粘膜炎发病机制的关键。此外,在某些情况下,
将发展为种植体周围炎,导致牙槽骨丢失和种植体失败。这个应用程序的目标是
以产生一种新颖的牙植入体构造,
提供紧密的牙龈组织-植入物密封,作为细菌侵入的屏障。这个聪明的牙医
植入系统是一种无电池系统,其将来自人类口腔运动的生物力学力(例如,
咀嚼或刷牙)转化为电能,并为发光二极管供电,
光疗当与持久的修复表面结合使用时,
精确的光疗系统避免了使用常规抗菌剂的问题。正在进行
研究表明红光和近红外光在维持人牙龈组织细胞活力方面是有效的
面对单一和多微生物的挑战。此外,覆膜修复表面几乎
完全抑制细菌定植。基于这些令人兴奋的支持数据,我们假设力-
为压电晶体供电,以产生红光和近红外光,并结合细菌防粘剂
净化创造了一个抗炎、促愈合的环境,提供了一个强大的软组织密封,
防止种植体周围炎的发展。我们预计,这种下一代反-
炎性、可吸收薄膜牙科植入物系统将增加功能,并提供一种新的策略,
预防和控制种植体周围疾病,尤其是高危人群,并降低种植体风险
失败
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Geelsu Hwang其他文献
Geelsu Hwang的其他文献
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{{ truncateString('Geelsu Hwang', 18)}}的其他基金
Bacterial Adhesion Inhibition and Biofilm Disruption by Adaptive Piezoelectric Biomaterial
自适应压电生物材料抑制细菌粘附和破坏生物膜
- 批准号:
10668030 - 财政年份:2023
- 资助金额:
$ 52.13万 - 项目类别:
Enzymatic approach for targeting mannans/EPS to disrupt cross-kingdom cariog
靶向甘露聚糖/EPS 的酶法可破坏跨界 cariog
- 批准号:
10436198 - 财政年份:2018
- 资助金额:
$ 52.13万 - 项目类别:
Enzymatic approach for targeting mannans/EPS to disrupt cross-kingdom cariog
靶向甘露聚糖/EPS 的酶法可破坏跨界 cariog
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10189551 - 财政年份:2018
- 资助金额:
$ 52.13万 - 项目类别:
Role of GtfB on S.mutans-C.albicans interactions and cariogenic biofilm formation
GTfB 在 S.mutans-C.albicans 相互作用和致龋生物膜形成中的作用
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9016967 - 财政年份:2016
- 资助金额:
$ 52.13万 - 项目类别:
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