Translational Multimodal Strategy for Peri-Implant Disease Prevention

种植体周围疾病预防的转化多模式策略

• 批准号: 10736860
• 负责人: Geelsu Hwang
• 金额: $ 52.13万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10736860
• 关键词: 3-Dimensional; Address; Adhesions; Adhesives; Affect; Age; Alveolar Bone Loss; Anti-Bacterial Agents; Anti-Inflammatory Agents; Apoptosis; Bacterial Adhesion; Bicuspid; Biomechanics; Bite Force; Bone Resorption; Cell Communication; Cell Proliferation; Cell Survival; Cell physiology; Cells; Clinical; Coculture Techniques; Crowns; Data; Dental General Practice; Dental Implants; Dental Plaque; Dental crowns; Development; Disease; Dose; Engineering; Environment; Epithelial Cells; Failure; Fibroblasts; Future; Generations; Gingiva; Goals; Head; Human; Implant; In Situ; Individual; Inflammation; Inflammation Mediators; Inflammatory; Inflammatory Response; Invaded; Joint Prosthesis; Ligature; Light; Limb Prosthesis; Longevity; Mastication; Measures; Mechanics; Mediating; Microbe; Microbial Biofilms; Modeling; Molar tooth; Motion; Mucositis; Operative Surgical Procedures; Oral; Osseointegration; Outcome; Pathogenesis; Patients; Periodontitis; Phenotype; Phototherapy; Populations at Risk; Production; Property; Protocols documentation; Recording of previous events; Resistance; Risk Reduction; Rupture; Sampling; Secure; Self Assessment; Signal Pathway; Silk; Smoking; Stimulus; Structure; Surface; System; Systemic disease; Testing; Tissues; Titanium; Tooth structure; Toothbrushing; United States; X-Ray Computed Tomography; alveolar bone; antimicrobial; antimicrobial peptide; clinical examination; clinical practice; cytokine; disorder prevention; dosage; efficacy evaluation; efficacy testing; electrical potential; experimental study; healing; human tissue; implantable device; in vivo Model; in vivo evaluation; innovation; keratinocyte; light emission; microCT; microbial; multimodality; next generation; novel; oral pathogen; particle; pathogenic microbe; peri-implantitis; photobiomodulation; porcine model; preservation; prevent; response; restoration; seal; self assembly; senescence; soft tissue; tissue culture

Dental implants have become an important routine component of dental practice with over five million fixtures placed annually in the United States and this number is expected to increase significantly in the future. The peri-implant soft tissue interface is less effective than natural teeth in resisting bacterial invasion, enhancing vulnerability to subsequent peri-implant disease. Peri-implant diseases are inflammatory conditions affecting the soft/hard tissues surrounding a functional dental implant. Plenty of experimental evidence indicates that the accumulation of dental plaque at the soft tissue-implant interface and the subsequent local inflammatory response seems to be key in the pathogenesis of peri-implant mucositis. Furthermore, in certain individuals, it will progress to peri-implantitis, resulting in alveolar bone loss and implant failure. The goal of this application is to create a novel dental implant construct that renders the implant-supported restoration antibiofilm while providing a tight gingival tissue-implant seal that serves as a barrier to bacterial invasion. This smart dental implant system is a battery-less system that converts biomechanical forces from human oral motions (e.g., chewing or tooth-brushing) into electrical energy and powers light-emitting diodes that enable in situ phototherapy. When used in combination with a long-lasting antibiofilm restorative surface, this self-powered precision phototherapy system circumvents problems with the use of conventional antimicrobials. Ongoing studies indicate that red and near-infrared light is effective in maintaining human gingival tissue cell viability in the face of mono- and multi-microbial challenges. Furthermore, the antibiofilm restorative surface almost completely inhibits bacterial colonization. Based on these exciting supporting data, we hypothesize that force- powering of piezoelectric crystals to produce red and near-infrared light combined with bacterial anti-adhesive restorations creates an anti-inflammatory, pro-healing environment that provides a robust soft-tissue seal and prevents the development of peri-implantitis. We anticipate that the creation of this next-generation anti- inflammatory, antibiofilm dental implant system would increase functionality and provide a new strategy to prevent and control peri-implant diseases, especially in populations at risk, and reduce the risk of implant failure.

牙科植入物已成为牙科实践的重要常规组成部分，超过500万个固定装置 每年在美国进行，预计这一数字将在未来大幅增加。的 种植体周围软组织界面在抵抗细菌侵袭、增强 易受随后的植入物周围疾病的影响。种植体周围疾病是影响 功能性牙科植入物周围的软/硬组织。大量的实验证据表明， 牙菌斑在软组织-种植体界面处的积聚以及随后的局部炎症 反应似乎是种植体周围粘膜炎发病机制的关键。此外，在某些情况下， 将发展为种植体周围炎，导致牙槽骨丢失和种植体失败。这个应用程序的目标是 以产生一种新颖的牙植入体构造， 提供紧密的牙龈组织-植入物密封，作为细菌侵入的屏障。这个聪明的牙医 植入系统是一种无电池系统，其将来自人类口腔运动的生物力学力（例如， 咀嚼或刷牙）转化为电能，并为发光二极管供电， 光疗当与持久的修复表面结合使用时， 精确的光疗系统避免了使用常规抗菌剂的问题。正在进行 研究表明红光和近红外光在维持人牙龈组织细胞活力方面是有效的 面对单一和多微生物的挑战。此外，覆膜修复表面几乎 完全抑制细菌定植。基于这些令人兴奋的支持数据，我们假设力- 为压电晶体供电，以产生红光和近红外光，并结合细菌防粘剂 净化创造了一个抗炎、促愈合的环境，提供了一个强大的软组织密封， 防止种植体周围炎的发展。我们预计，这种下一代反- 炎性、可吸收薄膜牙科植入物系统将增加功能，并提供一种新的策略， 预防和控制种植体周围疾病，尤其是高危人群，并降低种植体风险 失败