DONALD ALCENDOR, PHD, LAB STARTUP PACKAGE: KSHV AND CMV IN HIV

DONALD ALCENDOR，博士，实验室启动包：HIV 中的 KSHV 和 CMV

• 批准号: 7380799
• 负责人: Donald James Alcendor
• 金额: $ 35.09万
• 依托单位: MEHARRY MEDICAL COLLEGE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7380799
• 关键词: DONALD; ALCENDOR; PHD; LAB; STARTUP

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Before HAART in 1996, at a height of HIV/AIDS epidemic, the incidence of Kaposi¿s sarcoma (KS) increased 20,000 fold among homosexual males in the United States and KS is now the predominant HIV/AIDS related malignancy in Southern Africa. Antiretroviral therapy has reduced the incidence of KS in western countries however 99% of the estimated 40 to 60 million people infected with HIV have no access to these drugs and KS remains to be a problem worldwide. My research interest involves understanding mechanisms involved in KSHV disregulation of endothelial cell adhesion molecules which has implications for immune pathogenesis and tumorigenesis. Primary cytomegalovirus (CMV) infection in women during pregnancy can lead to life threatening neonatal disease and CMV infection in immunocompromised groups such transplant patients and individuals infected with HIV that are predisposed to severe morbidity and mortality associated with CMV. I have additional interest in cytomegalovirus dissemination in the brain of both congenital infected neonates as well CMV/HIV coinfections in the brain of AIDS patients. We are developing an infection model for both CMV and HIV in primary human brain microvascular endothelial cells to better understand CNS disease observed in these patients.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是中心的机构，不一定是研究者的机构。在 1996 年实施 HAART 之前，在艾滋病毒/艾滋病流行最严重的时期，美国男性同性恋者中卡波西肉瘤 (KS) 的发病率增加了 20,000 倍，目前卡波西肉瘤是南部非洲主要的艾滋病毒/艾滋病相关恶性肿瘤。抗逆转录病毒治疗降低了西方国家 KS 的发病率，但估计 40 至 6000 万 HIV 感染者中 99% 无法获得这些药物，KS 仍然是世界范围内的一个问题。我的研究兴趣涉及了解 KSHV 内皮细胞粘附分子失调的机制，这对免疫发病机制和肿瘤发生具有影响。妊娠期妇女的原发性巨细胞病毒 (CMV) 感染可导致危及生命的新生儿疾病，而免疫功能低下群体（例如移植患者和感染 HIV 的个体）容易出现与 CMV 相关的严重发病率和死亡率，因此 CMV 感染可导致危及生命。我对先天性感染新生儿大脑中的巨细胞病毒传播以及艾滋病患者大脑中 CMV/HIV 双重感染也很感兴趣。我们正在开发原代人脑微血管内皮细胞中 CMV 和 HIV 的感染模型，以更好地了解在这些患者中观察到的中枢神经系统疾病。