DONALD ALCENDOR, PHD, LAB STARTUP PACKAGE: KSHV AND CMV IN HIV

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在1996年HAART之前，在艾滋病毒/艾滋病流行的高峰期，卡波西肉瘤(KS)在美国同性恋男性中的发病率增加了2万倍，KS现在是南部非洲主要的艾滋病毒/艾滋病相关恶性肿瘤。抗逆转录病毒治疗降低了西方国家KS的发病率，然而，估计有4000万至6000万艾滋病毒感染者中的99%无法获得这些药物，KS仍然是一个世界性的问题。我的研究兴趣包括了解KSHV扰乱内皮细胞黏附分子的机制，这对免疫发病机制和肿瘤发生具有重要意义。 妊娠期妇女感染巨细胞病毒(CMV)可导致危及生命的新生儿疾病和免疫受损群体中的CMV感染，如移植患者和感染了CMV的人，这些人容易与CMV相关的严重发病率和死亡率。我还对巨细胞病毒在先天感染新生儿的大脑中的传播以及在艾滋病患者大脑中的CMV/HIV混合感染感兴趣。我们正在开发CMV和HIV在原代人脑微血管内皮细胞中的感染模型，以更好地了解在这些患者中观察到的中枢神经系统疾病。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Before HAART in 1996, at a height of HIV/AIDS epidemic, the incidence of Kaposi's sarcoma (KS) increased 20,000 fold among homosexual males in the United States and KS is now the predominant HIV/AIDS related malignancy in Southern Africa. Antiretroviral therapy has reduced the incidence of KS in western countries however 99% of the estimated 40 to 60 million people infected with HIV have no access to these drugs and KS remains to be a problem worldwide. My research interest involves understanding mechanisms involved in KSHV disregulation of endothelial cell adhesion molecules which has implications for immune pathogenesis and tumorigenesis. Primary cytomegalovirus (CMV) infection in women during pregnancy can lead to life threatening neonatal disease and CMV infection in immunocompromised groups such transplant patients and individuals infected with HIV that are predisposed to severe morbidity and mortality associated with CMV. I have additional interest in cytomegalovirus dissemination in the brain of both congenital infected neonates as well CMV/HIV coinfections in the brain of AIDS patients. We are developing an infection model for both CMV and HIV in primary human brain microvascular endothelial cells to better understand CNS disease observed in these patients.