DONALD ALCENDOR, PHD, LAB STARTUP PACKAGE: KSHV AND CMV IN HIV

DONALD ALCENDOR，博士，实验室启动包：HIV 中的 KSHV 和 CMV

• 批准号: 7961280
• 负责人: Donald James Alcendor
• 金额: $ 1.31万
• 依托单位: MEHARRY MEDICAL COLLEGE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2009-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7961280
• 关键词: AIDS related cancer; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Brain; Cell Adhesion Molecules; Central Nervous System Diseases; Computer Retrieval of Information on Scientific Projects Database; Country; Cytomegalovirus; Cytomegalovirus Infections; Disease; Endothelial Cells; Epidemic; Funding; Grant; HIV; Height; Highly Active Antiretroviral Therapy; Homosexuals; Human; Human Herpesvirus 8; Immune; Immunocompromised Host; Incidence; Individual; Infection; Institution; Kaposi Sarcoma; Lead; Life; Modeling; Morbidity - disease rate; Neonatal; Pathogenesis; Patients; Pharmaceutical Preparations; Pregnancy; Research; Research Personnel; Resources; Source; Southern Africa; Transplant Recipients; United States; United States National Institutes of Health; Woman; antiretroviral therapy; health disparity; interest; male; mortality; neonate; tumorigenesis

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Before HAART in 1996, at a height of HIV/AIDS epidemic, the incidence of Kaposi's sarcoma (KS) increased 20,000 fold among homosexual males in the United States and KS is now the predominant HIV/AIDS related malignancy in Southern Africa. Antiretroviral therapy has reduced the incidence of KS in western countries however 99% of the estimated 40 to 60 million people infected with HIV have no access to these drugs and KS remains to be a problem worldwide. My research interest involves understanding mechanisms involved in KSHV disregulation of endothelial cell adhesion molecules which has implications for immune pathogenesis and tumorigenesis. Primary cytomegalovirus (CMV) infection in women during pregnancy can lead to life threatening neonatal disease and CMV infection in immunocompromised groups such transplant patients and individuals infected with HIV that are predisposed to severe morbidity and mortality associated with CMV. I have additional interest in cytomegalovirus dissemination in the brain of both congenital infected neonates as well CMV/HIV coinfections in the brain of AIDS patients. We are developing an infection model for both CMV and HIV in primary human brain microvascular endothelial cells to better understand CNS disease observed in these patients.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 在1996年HAART之前，在HIV/AIDS流行的高峰期，卡波西肉瘤（KS）的发病率在美国同性恋男性中增加了20，000倍，并且KS现在是南部非洲主要的HIV/AIDS相关恶性肿瘤。抗逆转录病毒治疗已经降低了西方国家KS的发病率，但估计4000万至6000万艾滋病毒感染者中有99%无法获得这些药物，KS仍然是一个世界性的问题。我的研究兴趣包括了解KSHV对内皮细胞粘附分子的失调机制，这对免疫发病机制和肿瘤发生有影响。 妊娠期女性的原发性巨细胞病毒（CMV）感染可导致危及生命的新生儿疾病和免疫功能低下人群（如移植患者和感染HIV的个体）的CMV感染，这些人群易发生与CMV相关的严重发病率和死亡率。我对巨细胞病毒在先天性感染新生儿脑中的传播以及艾滋病患者脑中的CMV/HIV合并感染有额外的兴趣。我们正在开发一种在原代人脑微血管内皮细胞中CMV和HIV的感染模型，以更好地了解在这些患者中观察到的CNS疾病。