Echocardiography/Magnetocardiography In Fetal Hearts

胎儿心脏超声心动图/心磁图

• 批准号: 7147894
• 负责人: Janette F Strasburger
• 金额: $ 17.22万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7147894
• 关键词: arrhythmia; bioimaging /biomedical imaging; biomagnetism measurement; cardiography; clinical research; congenital heart disorder; diagnosis design /evaluation; diagnostic tests; early diagnosis; echocardiography; electrocardiography; embryo /fetus disorder; heart disorder diagnosis; heart failure; heart function; human pregnant subject; noninvasive diagnosis; patient oriented research

DESCRIPTION (provided by applicant): Fetal heart disease has an overall mortality of about 30%. Deaths from birth defects are the leading cause of infant mortality. Non-invasive echocardiographic/Doppler (echo/Doppler) heart rhythm and function assessment has become integral to the evaluation of high-risk fetuses with arrhythmias, conduction disease, structural cardiac defects, maternal SSA/SSB antibody exposure, hydrops fetalis, and other in utero conditions. While fetal Magnetocardiography (fMCG) is the best means presently for directly evaluating fetal cardiac rhythm and intervals, it is not readily available to clinicians. Assessment of accuracy, capabilities, and limitations of echo/Doppler-derived rhythm measurements is needed. No direct side-by-side cardiac interval validations have been performed between echo/Doppler and fMCG in a healthy fetal population, or in fetuses with disease. This is despite several ongoing studies using echo/Doppler interval measurement in the clinical stratification of fetuses with arrhythmias and SSA/Ro or SSB/La exposure. In 1997, we determined which echo/Doppler criteria could be used for electrocardiographic interval assessment in the neonate with supraventricular tachycardia (SVT) undergoing electrophysiologic testing. Direct electrocardiographic (EGG) and echo/Doppler measurements were simultaneously obtained. Severe disturbances in diastolic function were observed and characterized during SVT. The purpose of this present study is 1) to validate the non-invasive mechanical measurement of cardiac intervals using fMCG comparisons in a healthy control fetal population as well as in fetal disease, and 2) to expand the potential utility of echo/Doppler in better assessing the fetus with heart disease by incorporating non-traditional measurement techniques utilizing knowledge gained from fMCG arrhythmia analysis. This may lead to further integration of rhythm and function assessments in the fetus using two different, yet complimentary technologies.

描述（申请人提供）：胎心病的总体死亡率约为 30%。出生缺陷导致的死亡是婴儿死亡的主要原因。无创超声心动图/多普勒 (echo/Doppler) 心律和功能评估已成为评估患有心律失常、传导疾病、结构性心脏缺陷、母体 SSA/SSB 抗体暴露、胎儿水肿和其他子宫内情况的高危胎儿的重要组成部分。虽然胎儿心磁图 (fMCG) 是目前直接评估胎儿心律和间隔的最佳手段，但临床医生并不容易使用。需要评估回波/多普勒衍生节律测量的准确性、功能和局限性。在健康胎儿群体或患有疾病的胎儿中，尚未对回波/多普勒和 fMCG 进行直接并列心脏间隔验证。尽管有几项正在进行的研究使用回声/多普勒间隔测量对患有心律失常和 SSA/Ro 或 SSB/La 暴露的胎儿进行临床分层。 1997 年，我们确定了哪些回波/多普勒标准可用于接受电生理测试的室上性心动过速 (SVT) 新生儿的心电图间隔评估。 同时获得直接心电图（EGG）和回波/多普勒测量。在 SVT 期间观察到并描述了舒张功能的严重紊乱。本研究的目的是 1) 使用健康对照胎儿群体以及胎儿疾病中的 fMCG 比较来验证心率间隔的无创机械测量，以及 2) 通过利用从 fMCG 心律失常分析中获得的知识结合非传统测量技术，扩大回声/多普勒在更好地评估患有心脏病的胎儿方面的潜在效用。这可能会导致使用两种不同但互补的技术进一步整合胎儿的节律和功能评估。