Echocardiography/Magnetocardiography In Fetal Hearts

胎儿心脏超声心动图/心磁图

• 批准号: 7147894
• 负责人: Janette F Strasburger
• 金额: $ 17.22万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7147894
• 关键词: arrhythmia; bioimaging /biomedical imaging; biomagnetism measurement; cardiography; clinical research; congenital heart disorder; diagnosis design /evaluation; diagnostic tests; early diagnosis; echocardiography; electrocardiography; embryo /fetus disorder; heart disorder diagnosis; heart failure; heart function; human pregnant subject; noninvasive diagnosis; patient oriented research

DESCRIPTION (provided by applicant): Fetal heart disease has an overall mortality of about 30%. Deaths from birth defects are the leading cause of infant mortality. Non-invasive echocardiographic/Doppler (echo/Doppler) heart rhythm and function assessment has become integral to the evaluation of high-risk fetuses with arrhythmias, conduction disease, structural cardiac defects, maternal SSA/SSB antibody exposure, hydrops fetalis, and other in utero conditions. While fetal Magnetocardiography (fMCG) is the best means presently for directly evaluating fetal cardiac rhythm and intervals, it is not readily available to clinicians. Assessment of accuracy, capabilities, and limitations of echo/Doppler-derived rhythm measurements is needed. No direct side-by-side cardiac interval validations have been performed between echo/Doppler and fMCG in a healthy fetal population, or in fetuses with disease. This is despite several ongoing studies using echo/Doppler interval measurement in the clinical stratification of fetuses with arrhythmias and SSA/Ro or SSB/La exposure. In 1997, we determined which echo/Doppler criteria could be used for electrocardiographic interval assessment in the neonate with supraventricular tachycardia (SVT) undergoing electrophysiologic testing. Direct electrocardiographic (EGG) and echo/Doppler measurements were simultaneously obtained. Severe disturbances in diastolic function were observed and characterized during SVT. The purpose of this present study is 1) to validate the non-invasive mechanical measurement of cardiac intervals using fMCG comparisons in a healthy control fetal population as well as in fetal disease, and 2) to expand the potential utility of echo/Doppler in better assessing the fetus with heart disease by incorporating non-traditional measurement techniques utilizing knowledge gained from fMCG arrhythmia analysis. This may lead to further integration of rhythm and function assessments in the fetus using two different, yet complimentary technologies.

描述（由申请人提供）：胎儿心脏病的总死亡率约为30%。出生缺陷造成的死亡是婴儿死亡的主要原因。非侵入性超声心动图/多普勒（echo/Doppler）心律和功能评估已成为评估高危胎儿心律失常、传导疾病、结构性心脏缺陷、母体SSA/SSB抗体暴露、胎儿水肿和其他宫内疾病的不可或缺的手段。虽然胎儿心磁图（fMCG）是目前直接评估胎儿心脏节律和间期的最佳手段，但临床医生并不容易获得。需要评估回声/多普勒衍生心律测量的准确性、能力和局限性。尚未在健康胎儿人群或患病胎儿中进行超声/多普勒和fMCG之间的直接并行心脏间期验证。尽管有几项正在进行的研究使用回声/多普勒间期测量对心律失常和SSA/Ro或SSB/La暴露的胎儿进行临床分层，但仍存在这种情况。在1997年，我们确定了超声/多普勒标准可用于心电图间期评估的新生儿室上性心动过速（SVT）进行电生理测试。 直接心电图（EGG）和回声/多普勒测量同时获得。在室上性心动过速期间观察到舒张功能严重紊乱。本研究的目的是：1）在健康对照胎儿人群以及胎儿疾病中使用fMCG比较来验证心脏间期的无创机械测量，以及2）通过结合利用从fMCG心律失常分析获得的知识的非传统测量技术来扩展回波/多普勒在更好地评估患有心脏病的胎儿中的潜在效用。这可能导致使用两种不同但互补的技术进一步整合胎儿的节律和功能评估。