Simultaneous Echocardiography & Magnetocardiography In Fetal Heart Disease

同步超声心动图

• 批准号: 7268005
• 负责人: Janette F Strasburger
• 金额: $ 13.57万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7268005
• 关键词: Accounting; Adopted; Adult; Anatomy; Antibodies; Area; Arrhythmia; Atrioventricular Block; Cardiac; Cardiomyopathies; Caring; Cessation of life; Childhood; Classification; Clinical; Condition; Congenital Abnormality; Congenital Heart Defects; Defect; Diagnosis; Disease; Doctor of Medicine; Echocardiography; Electrocardiogram; Evaluation; Fetal Diseases; Fetal Heart; Fetus; Functional disorder; Grant; Health Care Costs; Heart; Heart Diseases; Heart failure; Hospitalization; Human; Hydrops Fetalis; Infant Mortality; Invasive; Knowledge; Laboratories; Lead; Life; Link; Long QT Syndrome; Magnetism; Measurement; Mechanics; Medicine; Methodology; Methods; Myocardial; Neonatal; Noise; Outcome; Patients; Performance; Play; Population; Pregnancy; Pregnant Women; Purpose; Research Personnel; Risk; Role; Side; Signal Transduction; Sinus; Stratification; Sudden Death; Supraventricular tachycardia; Techniques; Technology; Testing; Time; Universities; Validation; Week; Wisconsin; biomagnetism; blind; congenital heart disorder; cost; egg; fetal; fetus at risk; heart rhythm; in utero; mortality; neonate; novel; novel diagnostics

DESCRIPTION (provided by applicant): Fetal heart disease has an overall mortality of about 30%. Deaths from birth defects are the leading cause of infant mortality. Non-invasive echocardiographic/Doppler (echo/Doppler) heart rhythm and function assessment has become integral to the evaluation of high-risk fetuses with arrhythmias, conduction disease, structural cardiac defects, maternal SSA/SSB antibody exposure, hydrops fetalis, and other in utero conditions. While fetal Magnetocardiography (fMCG) is the best means presently for directly evaluating fetal cardiac rhythm and intervals, it is not readily available to clinicians. Assessment of accuracy, capabilities, and limitations of echo/Doppler-derived rhythm measurements is needed. No direct side-by-side cardiac interval validations have been performed between echo/Doppler and fMCG in a healthy fetal population, or in fetuses with disease. This is despite several ongoing studies using echo/Doppler interval measurement in the clinical stratification of fetuses with arrhythmias and SSA/Ro or SSB/La exposure. In 1997, we determined which echo/Doppler criteria could be used for electrocardiographic interval assessment in the neonate with supraventricular tachycardia (SVT) undergoing electrophysiologic testing. Direct electrocardiographic (EGG) and echo/Doppler measurements were simultaneously obtained. Severe disturbances in diastolic function were observed and characterized during SVT. The purpose of this present study is 1) to validate the non-invasive mechanical measurement of cardiac intervals using fMCG comparisons in a healthy control fetal population as well as in fetal disease, and 2) to expand the potential utility of echo/Doppler in better assessing the fetus with heart disease by incorporating non-traditional measurement techniques utilizing knowledge gained from fMCG arrhythmia analysis. This may lead to further integration of rhythm and function assessments in the fetus using two different, yet complimentary technologies.

描述(申请人提供)：胎儿心脏病的总死亡率约为30%。出生缺陷死亡是婴儿死亡的主要原因。无创超声心动图/多普勒(ECHO/多普勒)心率和功能评估已成为评估患有心律失常、传导疾病、结构性心脏缺陷、母亲SSA/SSB抗体暴露、胎儿积水和其他宫内情况的高危胎儿不可或缺的一部分。虽然胎儿心磁图(FMCG)是目前直接评估胎儿心率和间期的最好手段，但临床医生并不容易使用。需要对回声/多普勒衍生的节律测量的准确性、能力和局限性进行评估。在健康的胎儿群体或有疾病的胎儿中，没有在超声/多普勒和FMCG之间进行直接的并排心脏间期验证。尽管有几项正在进行的研究使用回波/多普勒间期测量对患有心律失常和SSA/Ro或SSB/La暴露的胎儿进行临床分层。1997年，我们确定了在接受电生理检查的新生儿室上性心动过速(SVT)患者中，哪些回声/多普勒标准可用于心电间期的评估。同时进行直接心电(EGG)和回声/多普勒测量。在室上性心动过速期间观察到严重的舒张期功能紊乱。本研究的目的是：1)验证在健康对照胎儿人群和胎儿疾病中使用FMCG比较对心脏间期进行无创性机械测量的有效性；2)通过结合非传统测量技术，利用从FMCG心律失常分析中获得的知识，扩展超声/多普勒在更好地评估患有心脏病的胎儿方面的潜在效用。这可能导致使用两种不同但互补的技术进一步整合胎儿的节律和功能评估。