Simultaneous Echocardiography & Magnetocardiography In Fetal Heart Disease

描述（由申请人提供）：胎儿心脏病的总死亡率约为30%。出生缺陷造成的死亡是婴儿死亡的主要原因。无创超声心动图/多普勒（回声/多普勒）心律和功能评估已成为评估高危胎儿心律失常、传导疾病、心脏结构性缺陷、母体SSA/SSB抗体暴露、胎儿水肿和其他宫内情况不可或缺的一部分。虽然胎儿心脏磁图（fMCG）是目前直接评估胎儿心律和间隔的最佳手段，但它并不容易为临床医生所用。需要评估回波/多普勒衍生节律测量的准确性、能力和局限性。在健康胎儿群体或患有疾病的胎儿中，没有对回声/多普勒和fMCG进行直接的心脏间期验证。尽管有几项正在进行的研究使用回声/多普勒间隔测量对患有心律失常和SSA/Ro或SSB/La暴露的胎儿进行临床分层。1997年，我们确定了超声/多普勒标准可用于进行电生理测试的室上性心动过速（SVT）新生儿的心电图间期评估。直接心电图（EGG）和超声/多普勒测量同时进行。在SVT期间观察和表征了严重的舒张功能紊乱。本研究的目的是1)验证在健康对照胎儿群体和胎儿疾病中使用fMCG比较的无创心脏间期机械测量方法，以及2)利用从fMCG心律失常分析中获得的知识，结合非传统测量技术，扩大超声/多普勒在更好地评估患有心脏病的胎儿方面的潜在应用。这可能会导致使用两种不同但互补的技术进一步整合胎儿的节律和功能评估。

DESCRIPTION (provided by applicant): Fetal heart disease has an overall mortality of about 30%. Deaths from birth defects are the leading cause of infant mortality. Non-invasive echocardiographic/Doppler (echo/Doppler) heart rhythm and function assessment has become integral to the evaluation of high-risk fetuses with arrhythmias, conduction disease, structural cardiac defects, maternal SSA/SSB antibody exposure, hydrops fetalis, and other in utero conditions. While fetal Magnetocardiography (fMCG) is the best means presently for directly evaluating fetal cardiac rhythm and intervals, it is not readily available to clinicians. Assessment of accuracy, capabilities, and limitations of echo/Doppler-derived rhythm measurements is needed. No direct side-by-side cardiac interval validations have been performed between echo/Doppler and fMCG in a healthy fetal population, or in fetuses with disease. This is despite several ongoing studies using echo/Doppler interval measurement in the clinical stratification of fetuses with arrhythmias and SSA/Ro or SSB/La exposure. In 1997, we determined which echo/Doppler criteria could be used for electrocardiographic interval assessment in the neonate with supraventricular tachycardia (SVT) undergoing electrophysiologic testing. Direct electrocardiographic (EGG) and echo/Doppler measurements were simultaneously obtained. Severe disturbances in diastolic function were observed and characterized during SVT. The purpose of this present study is 1) to validate the non-invasive mechanical measurement of cardiac intervals using fMCG comparisons in a healthy control fetal population as well as in fetal disease, and 2) to expand the potential utility of echo/Doppler in better assessing the fetus with heart disease by incorporating non-traditional measurement techniques utilizing knowledge gained from fMCG arrhythmia analysis. This may lead to further integration of rhythm and function assessments in the fetus using two different, yet complimentary technologies.