Mechanistic Studies of palladium-catalysed C-C coupling reactions of carbon acids

钯催化碳酸C-C偶联反应的机理研究

• 批准号: 2787007
• 金额: --
• 依托单位: CARDIFF UNIVERSITY
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2787007
• 关键词: Mechanistic; Studies; palladium; catalysed; coupling

The project involves studies of Pd-catalysed C-C coupling reactions of carbon acids. Kinetic and mechanistic studies (physical organic chemistry) will be combined with advanced electron microscopy (using Cardiff University's brand-new Aberration-Corrected Scanning Transmission Electron Microscope (EM) at the Translational Research Hub). Custom data analysis approaches will be used to develop quantitative and mechanistic understanding of the reactions to support rational choice of reaction conditions and scale up and reduce palladium need. We will focus on understanding the behaviour of palladium catalysts under reaction conditions, including any nanoparticle formation, and the interplay between reactants, catalyst, by- and side-products, solvents and additives. For example, you will correlate reaction kinetics with analysis of EM images using artificial intelligence.

该项目涉及对碳酸PD催化的C-C偶联反应的研究。动力学和机械研究（物理有机化学）将与先进的电子显微镜（使用Cardiff University在转化研究中心的全新差异扫描传输电子显微镜（EM））结合使用。自定义数据分析方法将用于对反应的定量和机械理解，以支持反应条件的合理选择并扩大并减少钯的需求。我们将专注于在反应条件下（包括任何纳米颗粒形成）以及反应物，催化剂，副产品和副产物，溶剂和添加剂之间的相互作用，了解钯催化剂的行为。例如，您将使用人工智能将反应动力学与对EM图像的分析相关联。