EPSRC funded EngD: 3D printing of complex dressings for the regeneration of diabetic foot ulcers

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Diabetic Foot Ulcers (DFU) are open chronic wounds on the feet of diabetes patients that can lead to amputation if not managed correctly. DFU are a major burden to each patient and to the healthcare system as Ulcer healing times can range from one month to years and demand intensive wound care efforts. DFUs are subclassified into three categories: ischemic, neuropathic, and neuroischemic (most prevalent). In the case of neuropathic etiology, Ulcers are caused by lack of sensation in the foot leading to pressure points and abrasions which develop into open wounds. To address the high medical need in these patients, the treatment goal is a) to accelerate wound healing, b) to prevent recurrence, to c) avoid amputation ultimately. The team at UoB have developed a method to produce trilayered cell containing skin with a close resemblance to human tissues. In this project we will work closely to further develop this technology so that it is able to restore complex wounds, have the colour of non-pathological tissue, and ultimately seamlessly regenerate these often life changing wounds.