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Optimisation of extraction and purification methods (EPM) of high-value fucoidan from Scottish ocean-farmed seaweed for use as an antiviral and antimi

苏格兰海洋养殖海藻中高价值岩藻依聚糖的提取和纯化方法 (EPM) 的优化，用作抗病毒和抗病毒药物

基本信息

批准号：
2796234
负责人：
金额：
--
依托单位：
University of Edinburgh
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2022
资助国家：
英国
起止时间：
2022 至无数据
项目状态：
未结题

来源：
https://gtr.ukri.org/projects?ref=studentship-2796234
关键词：
Optimisation extraction purification methods EPM

项目摘要

The purpose of this PhD is to investigate the feasibility of producing fucoidan from farmed Scottish seaweed for use in antiviral and anti-inflammatory drugs. Fucoidan is a component in brown seaweed and has applications in pharmaceuticals and cosmetics. The properties of this chemical are affected by its structure and bioactivity characteristics.This project will involve a collaboration between the school of engineering, the medical school and an industrial partner BioMara Ltd. This project will have 3 parts; The first of these is the collection of seaweed and extraction this will potentially involve the visiting of farms sourced by BioMara for collection. The fucoidan in the seaweed would then be extracted using various methods. Next, the extracted fucoidan would then be purified again using varying methods such as chromatography as well as more novel methods. These stages will be carried out under the supervision of Dr Simone Dimartino in the School of Engineering. The final stage is the analysis of the samples in this the material produced will be tested for its suitability for use as antiviral and anti-inflammatory drugs. This stage would be supervised by Dr Richard Sloan in the Medical School.The PhD will look to optimise the extraction and purification processes to produce fucoidan with enhanced properties for use in drugs. Multiple purification processes will be considered such as membrane separation processes and affinity-based chromatography. These methods plus other potentially novel methods will be considered to see which yields fucoidan with the most useful characteristics.

本博士学位的目的是研究从养殖的苏格兰海藻中生产岩藻多糖用于抗病毒和抗炎药物的可行性。褐藻糖胶是褐藻中的一种成分，在药品和化妆品中有应用。该化学品的性质受其结构和生物活性特征的影响。该项目将涉及工程学院，医学院和工业合作伙伴BioMara Ltd.之间的合作。该项目将包括3个部分;第一部分是海藻的收集和提取，这可能涉及访问BioMara采购的农场进行收集。海藻中的褐藻糖胶随后将使用各种方法提取。接下来，提取的岩藻依聚糖将使用不同的方法如色谱法以及更新颖的方法再次纯化。这些阶段将在工程学院Simone Dimartino博士的监督下进行。最后一个阶段是对样品进行分析，将测试所生产的材料是否适合用作抗病毒和抗炎药物。这一阶段将由医学院的Richard Sloan博士监督。该博士将寻求优化提取和纯化过程，以生产具有增强药物特性的岩藻聚糖。将考虑多种纯化工艺，例如膜分离工艺和基于亲和的色谱法。这些方法加上其他潜在的新方法将被考虑，看看哪种方法产生的岩藻依聚糖具有最有用的特性。