Epigenetic profiling for detecting long lasting toxic effects on germline development in vitro

表观遗传分析用于检测体外种系发育的长期持续毒性作用

• 批准号: 2812990
• 金额: --
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2812990
• 关键词: Epigenetic; profiling; detecting; long; lasting

The potential impact of either environmental or pharmacological agents on the male or female germlines remains an incredibly poorly understood area of toxicology, particularly in mammalian systems. Studies have anecdotally provided some evidence of drugs (Sodium Valproate) or chemicals (Bisphenol-A) impacting on the germline, and particularly inducing epigenetic changes to subsequent generations, as opposed to genotoxic effects. However, the reproducibility and human relevance of many of these studies has been challenged, with little to no mechanistic information on how these changes may occur, be transmitted and persist into the next generation(s). This project will address this using epigenetic profiling for detecting long lasting toxic effects on germline development in vitro.

环境或药理学因素对男性或女性生殖系的潜在影响，在毒理学领域，特别是在哺乳动物系统中，仍然是一个知之甚少的领域。研究提供了一些证据，证明药物（丙戊酸钠）或化学物质（双酚a）影响生殖系，特别是诱导后代的表观遗传变化，而不是遗传毒性作用。然而，许多这些研究的可重复性和人类相关性受到了挑战，几乎没有关于这些变化如何发生、传播和持续到下一代的机制信息。本项目将利用表观遗传分析来解决这一问题，以检测对体外生殖细胞发育的长期毒性作用。