Assessment of right hemisphere auditory speech function

右半球听觉言语功能评估

• 批准号: 7032984
• 负责人: Dana F. Boatman
• 金额: $ 23.93万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2008-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7032984
• 关键词: auditory cortex; auditory pathways; behavior test; behavioral /social science research tag; brain electrical activity; brain imaging /visualization /scanning; brain mapping; cerebral dominance; clinical research; diffusion magnetic resonance imaging; disease /disorder proneness /risk; electrophysiology; epilepsy; functional magnetic resonance imaging; human subject; mathematical model; nervous system disorder therapy; neural information processing; neurosurgery; patient oriented research; postoperative complications; speech disorder diagnosis; speech recognition; statistics /biometry; therapy adverse effect

DESCRIPTION (provided by applicant): The long-term goal of the research proposed is develop and test a clinical paradigm to identify prospectively right hemisphere (RH) seizure resection patients at risk for post-surgical speech perception deficits. Based on preliminary studies, we hypothesize that RH auditory areas, normally recruited to compensate for degradation of the speech signal under adverse listening conditions, are disrupted by surgery and/or chronic seizure effects. To test this hypothesis, we will implement three methodological approaches to assess the functional and structural integrity of the auditory system before surgery. We will then test the feasibility and potential clinical utility of combining these methods into a single clinical paradigm. First, we will implement repeated-measures behavioral testing using standardized and experimental tasks. Statistical modeling will help to identify resection parameters (size, location) associated with post-surgical behavioral auditory deficits. Second, electrophysiology studies will be performed to provide objective measures of auditory function and to investigate inter-hemispheric differences. Third, patients will undergo pre-surgical neuroimaging studies to identify functional abnormalities of cortical organization (fMRI), and structural abnormalities of auditory cortex (volumetric MRI) and the underlying white matter pathways (diffusion tensor MRI). Electrophysiology and neuroimaging results will be correlated with patients' behavioral performances. This research project constitutes the initial phase of a long-term research effort to investigate the neural bases of auditory dysfunction in chronic seizure patients. The feasibility studies proposed are well suited to the goals of the R21 program; We will integrate behavioral, electrophysiological, neuroimaging, and statistical methods to develop a new clinical paradigm. Completion of this initial research project will provide the basis for future investigations.

描述（由申请人提供）：提出的研究的长期目标是开发和测试临床范式，以识别前瞻性右半球（RH）癫痫发作切除术患者，患有手术后语音感知缺陷的风险。基于初步研究，我们假设通常招募的RH听觉区域是为了补偿不良听力条件下语音信号的退化，受到手术和/或慢性癫痫发作的影响。为了检验这一假设，我们将采用三种方法学方法来评估手术前听觉系统的功能和结构完整性。然后，我们将测试将这些方法合并为单个临床范式的可行性和潜在临床实用性。首先，我们将使用标准化和实验任务实施重复测量行为测试。统计建模将有助于确定与手术后行为听觉缺陷相关的切除参数（大小，位置）。其次，将进行电生理研究，以提供听觉功能的客观度量并研究半球间差异。第三，患者将接受手术前神经影像学研究，以鉴定皮质组织（fMRI）的功能异常，以及听觉皮层（体积MRI）的结构异常和基本的白质途径（扩散张量MRI）。电生理学和神经成像结果将与患者的行为表现相关。 该研究项目构成了长期研究工作的初始阶段，旨在研究慢性癫痫发作患者的听觉功能障碍的神经碱基。提出的可行性研究非常适合R21计划的目标；我们将整合行为，电生理，神经影像学和统计方法，以开发新的临床范式。最初的研究项目的完成将为未来的调查提供基础。