Impedance Threshold Value for Improving Standard CPR

改善标准心肺复苏的阻抗阈值

基本信息

  • 批准号:
    6884950
  • 负责人:
  • 金额:
    $ 102.35万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2000
  • 资助国家:
    美国
  • 起止时间:
    2000-09-15 至 2008-01-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Despite the widespread practice of basic and advanced life support, over 1000 patients die each day in the United States from an out-of-hospital cardiac arrest. Even though they receive standard cardiopulmonary resuscitation (sCPR) the average national survival to hospital discharge for these patients is less than 5%. The applicants have developed the inspiratory impedance threshold device (ITD) to increase negative intrathoracic pressure during the decompression phase of sCPR, thereby doubling forward blood flow. The Phase 2 clinical trial demonstrated that intensive care unit admission rate (primary study endpoint) in patients with an initial heart rhythm of pulseless electrical activity increased from 19% to 52% (p=0.02). During Phase 2 investigators also discovered a fundamental new principle of blood flow during CPR: an inverse relationship between intrathoracic pressure and coronary perfusion pressure as well as cerebral perfusion pressure and survival rates. With increased intrathoracic pressure, coronary and cerebral perfusion pressures, as well as survival rates, decreased. The Phase 2 research further lead to the discovery that during sCPR ventilation rates and duration are often excessive and that the chest is often not allowed to fully recoil after each compression. Each of these common clinical errors was electronically recorded for the first time and then shown to be detrimental, if not deadly, in animal models of cardiac arrest. Based upon these Phase II results the applicants have improved the ITD by adding a ventilation timing light to guide proper ventilation and developed a new and improved hand position for sCPR to help promote full chest wall recoil. Another way to assure that the critically important full chest recoil occurs after each chest compression is by using active compression decompression (ACD) CPR, a technique also developed by the applicants that utilizes a hand held device. Based upon these Phase 2 results, the Phase 2 continuation research will be conducted to obtain sufficient clinical data for regulatory clearance for the ITD as a technology intended to improve 24-hour survival rates after cardiac arrest. A pivotal clinical trial is proposed in the form of a prospective, randomized, two-site clinical trial to: 1) determine the 24-hour survival rate when using the ITD with improved sCPR, and 2) to determine the 24-hour survival rate when using the ITD and assuring full chest wall recoil with ACD CPR. With 400,000 out-of-hospital deaths from cardiac arrest in the United States alone, widespread application of this technology could result in 50,000 additional survivors per year.
描述(由申请人提供):

项目成果

期刊论文数量(0)
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KEITH G LURIE其他文献

KEITH G LURIE的其他文献

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{{ truncateString('KEITH G LURIE', 18)}}的其他基金

Non-invasive Extra-Corporeal Circulator for Prolonged Resuscitation
用于长时间复苏的无创体外循环器
  • 批准号:
    7746747
  • 财政年份:
    2009
  • 资助金额:
    $ 102.35万
  • 项目类别:
Intrathoracic Pressure Regulation for the Treatment of Septic Shock
胸内压力调节治疗感染性休克
  • 批准号:
    7671152
  • 财政年份:
    2009
  • 资助金额:
    $ 102.35万
  • 项目类别:
Resuscitation--impedance threshold devices in pediatrics
复苏——儿科阻抗阈值装置
  • 批准号:
    7053810
  • 财政年份:
    2006
  • 资助金额:
    $ 102.35万
  • 项目类别:
Novel non-invasive device for treatment of elevated intracranial pressures
用于治疗颅内压升高的新型非侵入性装置
  • 批准号:
    7909277
  • 财政年份:
    2006
  • 资助金额:
    $ 102.35万
  • 项目类别:
Resuscitation using novel impedance threshold devices in pediatrics
在儿科中使用新型阻抗阈值设备进行复苏
  • 批准号:
    8538490
  • 财政年份:
    2006
  • 资助金额:
    $ 102.35万
  • 项目类别:
Novel non-invasive device for treatment of elevated intracranial pressures
用于治疗颅内压升高的新型非侵入性装置
  • 批准号:
    8136511
  • 财政年份:
    2006
  • 资助金额:
    $ 102.35万
  • 项目类别:
Resuscitation using novel impedance threshold devices in pediatrics
在儿科中使用新型阻抗阈值设备进行复苏
  • 批准号:
    8308728
  • 财政年份:
    2006
  • 资助金额:
    $ 102.35万
  • 项目类别:
Resuscitation using novel impedance threshold devices in pediatrics
在儿科中使用新型阻抗阈值设备进行复苏
  • 批准号:
    7191717
  • 财政年份:
    2006
  • 资助金额:
    $ 102.35万
  • 项目类别:
Novel non-invasive device for treatment of elevated intracranial pressures
用于治疗颅内压升高的新型非侵入性装置
  • 批准号:
    7053851
  • 财政年份:
    2006
  • 资助金额:
    $ 102.35万
  • 项目类别:
Intrathoracic Pressure Regulator for Resuscitation
用于复苏的胸内压力调节器
  • 批准号:
    6999410
  • 财政年份:
    2005
  • 资助金额:
    $ 102.35万
  • 项目类别:

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