Disrupting and Delivering: A New Approach to Tackling Biofilm Infections

在这个项目中，我们的目标是使用物理刺激和靶向脂质体传递来干扰和敏化用于传递抗微生物药物的生物膜。主要的焦点将是耐药肺部感染，使用靶向递送给革兰氏阴性细菌。我们将开发一个基于微流控的高通量筛选平台，结合声学操纵和光学镊子来评估治疗方法，并在配方开发过程中使用一系列生物物理技术来表征它们

In this project we aim to use physical stimuli and targeted liposomal delivery to disrupt and sensitise biofilms for the delivery of antimicrobial drugs. The primary focus will be on antibiotic-resistant lung infections, using targeted delivery to Gram-negative bacteria. We will develop a microfluidic-based high throughput screening platform combining acoustic manipulation and optical tweezers to evaluate the therapeutics, and use a range of biophysical techniques to characterise them during formulation development