Disrupting and Delivering: A New Approach to Tackling Biofilm Infections

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In this project we aim to use physical stimuli and targeted liposomal delivery to disrupt and sensitise biofilms for the delivery of antimicrobial drugs. The primary focus will be on antibiotic-resistant lung infections, using targeted delivery to Gram-negative bacteria. We will develop a microfluidic-based high throughput screening platform combining acoustic manipulation and optical tweezers to evaluate the therapeutics, and use a range of biophysical techniques to characterise them during formulation development